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Roxithromycin

Known as: (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-d-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-(2-methoxyethoxymethoxyimino)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one, RXM, Roxithromycin [Chemical/Ingredient] 
Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (1)

Anti-Bacterial Agents

Narrower (7)

BiaxsigO-demethyl-roxithromycinRU 28965RU 965
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays.
2009
2009
On-line coupling of solid-phase extraction to liquid chromatography-tandem mass spectrometry for the determination of macrolide antibiotics in environmental water.
2008
2008
Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF‐κB
Background and objective:  To examine the effect of a 14‐membered ring macrolide on airway mucus hypersecretion in rats treated… 
Highly Cited
1999
Highly Cited
1999
Effects of erythromycin on human peripheral neutrophil apoptosis
1999
1999
In vitro activity of the novel ketolide HMR 3647 and comparative oral antibiotics against Canadian respiratory tract isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella…
Highly Cited
1998
Highly Cited
1998
Roxithromycin treatment for diarrhoea caused by Cryptosporidium spp. in patients with AIDS.
In view of the action of newer macrolide antibiotics on intracellular protozoa, we have investigated the efficacy of… 
1995
1995
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products.
Highly Cited
1992
Highly Cited
1992
Roxithromycin in Lyme borreliosis: discrepant results of an in vitro and in vivo animal susceptibility study and a clinical trial in patients with erythema migrans.
A new semisynthetic macrolide roxithromycin was evaluated for its potential use in the treatment of Lyme borreliosis. Using a… 
Highly Cited
1991
Highly Cited
1991
The diffusion of clarithromycin and roxithromycin into nasal mucosa, tonsil and lung in humans.
The diffusion of clarithromycin and roxithromycin into respiratory tract tissues was studied in 174 adult patients undergoing… 
Highly Cited
1988
Highly Cited
1988
In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin
The in vitro activity of azithromycin (CP 62,993 or XZ-450) against Haemophilus influenzae was greater than that of three other… 
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