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Ricin A Chain

Known as: A Chain, Ricin 
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health

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Ricin

Papers overview

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2009
2009
A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.
Ricin is a ribosome inactivating protein that catalytically removes a universally conserved adenine from the alpha-sarcin/ricin… Expand
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2004
2004
High-performance liquid chromatography-mass selective detection assay for adenine released from a synthetic RNA substrate by ricin A chain.
High-performance liquid chromatography (HPLC) and selected ion monitoring mass spectrometry (MS) were used to develop a… Expand
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Highly Cited
1997
Highly Cited
1997
Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin.
In the present study, we developed an antitumor immunoconjugate that appears to be promising as a novel curative antitumor agent… Expand
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1995
1995
Ricin A chain can be chemically cross-linked to the mammalian ribosomal proteins L9 and L10e.
Indirect immunofluorescence studies revealed that when fixed, permeabilized cultured human cells were incubated with ricin A… Expand
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1995
1995
Cell-specific delivery of bacteriophage-encapsidated ricin A chain.
We have used covalent coupling of deglycosylated ricin A chain (RAC) to the assembly initiation/translational repression RNA stem… Expand
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1994
1994
Introduction of a disulfide bond into ricin A chain decreases the cytotoxicity of the ricin holotoxin.
Wild type ricin A chain (RTA) contains two cysteine residues (Cys171 and Cys259). Cys259 forms the interchain disulfide bond of… Expand
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1993
1993
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
An Escherichia coli expression system was used to produce recombinant ricin A chain (RTA) and RTA modified either by the addition… Expand
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1992
1992
Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography.
Active site residues of ricin A chain were analyzed by site-directed mutagenesis and X-ray diffraction to help assess their roles… Expand
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1990
1990
Dual effects of the ricin A chain on protein synthesis in rabbit reticulocyte lysate. Inhibition of initiation and translocation.
Ricin A chain caused inhibition of protein synthesis by reticulocyte lysate with concomitant depurination of 28S rRNA. The… Expand
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1982
1982
Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.
The toxic subunit of ricin has been conjugated by a disulfide bound to a monoclonal murine antibody (J-5) specific for the common… Expand
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