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Ricin A Chain

Known as: A Chain, Ricin 
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health

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Ricin

Papers overview

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2006
2006
A novel designed single domain antibody on 3-D structure of ricin A chain remarkably blocked ricin-induced cytotoxicity.
Highly Cited
1995
Highly Cited
1995
Ricin A Chain Can Be Chemically Cross-linked to the Mammalian Ribosomal Proteins L9 and L10e (*)
Indirect immunofluorescence studies revealed that when fixed, permeabilized cultured human cells were incubated with ricin A… 
1995
1995
Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus.
Ricin A chain (RTA) mutants which had been modified by the addition of three lysine residues, three lysines and an alanine, or… 
1990
1990
Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin.
A panel of immunotoxins was constructed by chemically attaching the ribosome-inactivating proteins abrin A chain, ricin A chain… 
1990
1990
Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin.
In the present study, immunotoxins (ITs) containing ricin A chain (RA) and anti-human T leukemia monoclonal antibodies SN1 and… 
1989
1989
Recombinant ricin A chain conjugated to monoclonal antibodies: improved tumor cell inhibition in the presence of lysosomotropic compounds.
Recombinant ricin A chain was chemically linked to monoclonal antibodies directed toward human breast cancer cells, a human T… 
1988
1988
Endocytosis and intracellular routing of an antibody-ricin A chain conjugate.
An immunotoxin (IT) was prepared from monoclonal antibody (MoAb) 115D8 and ricin A chain. MoAb 115D8 is directed against the… 
1985
1985
Adult T cell leukemia: a potential target for ricin A chain immunotoxins.
Adult T cell leukemia (ATL) is an almost uniformly fatal malignancy of mature T cells associated with human T cell leukemia… 
1984
1984
Specific killing of human T-leukemia cells by immunotoxins prepared with ricin A chain and monoclonal anti-human T-cell leukemia antibodies.
In this study, immunotoxins containing monoclonal anti-human T-cell leukemia antibodies are shown to be capable of specific… 
1982
1982
Chinese Hamster Cell Variants Resistant to the A Chain of Ricin Carry Altered Ribosome Function
Ricin, a toxic lectin from Ricinus communis, is composed of two different polypeptide chains, A and B, and the ricin A chain (RA… 
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