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Ricin A Chain

Known as: A Chain, Ricin 
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health

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Ricin

Papers overview

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Highly Cited
1995
Highly Cited
1995
Ricin A Chain Can Be Chemically Cross-linked to the Mammalian Ribosomal Proteins L9 and L10e (*)
Indirect immunofluorescence studies revealed that when fixed, permeabilized cultured human cells were incubated with ricin A… 
1995
1995
Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus.
Ricin A chain (RTA) mutants which had been modified by the addition of three lysine residues, three lysines and an alanine, or… 
Highly Cited
1993
Highly Cited
1993
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
An Escherichia coli expression system was used to produce recombinant ricin A chain (RTA) and RTA modified either by the addition… 
1990
1990
Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin.
A panel of immunotoxins was constructed by chemically attaching the ribosome-inactivating proteins abrin A chain, ricin A chain… 
1989
1989
Recombinant ricin A chain conjugated to monoclonal antibodies: improved tumor cell inhibition in the presence of lysosomotropic compounds.
Recombinant ricin A chain was chemically linked to monoclonal antibodies directed toward human breast cancer cells, a human T… 
1988
1988
Endocytosis and intracellular routing of an antibody-ricin A chain conjugate.
An immunotoxin (IT) was prepared from monoclonal antibody (MoAb) 115D8 and ricin A chain. MoAb 115D8 is directed against the… 
1985
1985
Adult T cell leukemia: a potential target for ricin A chain immunotoxins.
Adult T cell leukemia (ATL) is an almost uniformly fatal malignancy of mature T cells associated with human T cell leukemia… 
1984
1984
Specific killing of human T-leukemia cells by immunotoxins prepared with ricin A chain and monoclonal anti-human T-cell leukemia antibodies.
In this study, immunotoxins containing monoclonal anti-human T-cell leukemia antibodies are shown to be capable of specific… 
Highly Cited
1982
Highly Cited
1982
Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.
The toxic subunit of ricin has been conjugated by a disulfide bound to a monoclonal murine antibody (J-5) specific for the common… 
1982
1982
Chinese Hamster Cell Variants Resistant to the A Chain of Ricin Carry Altered Ribosome Function
Ricin, a toxic lectin from Ricinus communis, is composed of two different polypeptide chains, A and B, and the ricin A chain (RA… 
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