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Ricin A Chain

Known as: A Chain, Ricin 
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
02419902016

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1 relation

Broader (1)

Ricin

Related mentions per year

Related mentions per year

1966-2018
1960198020002020
Ricin A Chain
Ricin

Papers overview

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2016
2016
Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial VH:VL libraries from immunized animals.
Ricin is a toxin that could potentially be used as a bioweapon. We identified anti-ricin A chain antibodies by sequencing the… (More)
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2016
2016
Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2
Ricin is a type 2 ribosome-inactivating protein (RIP), containing a catalytic A chain and a lectin-like B chain. It inhibits… (More)
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2016
2016
Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.
Ricin is a potent ribotoxin that is considered a bioterror threat due to its ease of isolation and possibility of aerosolization… (More)
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2013
2013
Antibody to Ricin A Chain Hinders Intracellular Routing of Toxin and Protects Cells Even after Toxin Has Been Internalized
BACKGROUND Mechanisms of antibody-mediated neutralization are of much interest. For plant and bacterial A-B toxins, A chain… (More)
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2009
2009
Ricin A Chain Insertion into Endoplasmic Reticulum Membranes Is Triggered by a Temperature Increase to 37 °C*S⃞
Steady-state anisotropy of DPH incorporated in KRMs-For the incorporation of 1,6-diphenyl-1,3,5-hexatriene (DPH) into KRMs, 0.5… (More)
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2006
2006
Phase I Evaluation of an Anti-Breast Carcinoma Monoclonal Antibody 260F9- Recombinant Ricin A Chain Immunoconjugate1
Four women with metastatic breast cancer were treated with monoclo nal antibody 260K9-recombinant ricin A chain, a ricin A chain… (More)
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2006
2006
Toxicity and Immunogenicity of Monoclonal Antimelanoma Antibody-Ricin A Chain Immunotoxin in Rats1
This study was performed to assess the subacute toxicity and immunogenicity in rats of XOMAZYME-MEL, an antimelanoma monoclonal… (More)
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2006
2006
Pharmacokinetics in the Rat of a Panel of Immunotoxins Made with Abrin A Chain, Ricin A Chain, Gelonin, and Momordin1
A panel of immunotoxins was constructed by chemically attaching the ribosome-inactivating proteins abrin A chain, ricin A chain… (More)
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2000
2000
A Phase I Study of Combination Therapy with Immunotoxins IgG- HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(1), CD22(1) B Cell Lymphoma
This study used an 8-day continuous infusion regimen of a 1:1 mixture of two immunotoxins (ITs) prepared from deglycosylated… (More)
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1990
1990
Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin.
In the present study, immunotoxins (ITs) containing ricin A chain (RA) and anti-human T leukemia monoclonal antibodies SN1 and… (More)
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