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Ricin A Chain

Known as: A Chain, Ricin 
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health

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Ricin

Papers overview

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2005
2005
Endoplasmic Reticulum-Associated Degradation of Ricin A Chain Has Unique and Plant-Specific Features1
Proteins that fail to fold in the endoplasmic reticulum (ER) or cannot find a pattern for assembly are often disposed of by a… 
Highly Cited
1995
Highly Cited
1995
Cell-specific delivery of bacteriophage-encapsidated ricin A chain.
We have used covalent coupling of deglycosylated ricin A chain (RAC) to the assembly initiation/translational repression RNA stem… 
Highly Cited
1995
Highly Cited
1995
Ricin A Chain Can Be Chemically Cross-linked to the Mammalian Ribosomal Proteins L9 and L10e (*)
Indirect immunofluorescence studies revealed that when fixed, permeabilized cultured human cells were incubated with ricin A… 
Highly Cited
1993
Highly Cited
1993
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
An Escherichia coli expression system was used to produce recombinant ricin A chain (RTA) and RTA modified either by the addition… 
Highly Cited
1992
Highly Cited
1992
Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography.
Active site residues of ricin A chain were analyzed by site-directed mutagenesis and X-ray diffraction to help assess their roles… 
Highly Cited
1989
Highly Cited
1989
Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild‐type and mutant polypeptides.
When recombinant ricin A chain transcripts are translated in a rabbit reticulocyte lysate the ribosomes are rapidly inactivated… 
Highly Cited
1989
Highly Cited
1989
Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates.
mAb 907 is directed against the envelope protein of the HIV. The epitope recognized by this antibody is expressed in moderate… 
1988
1988
Endocytosis and intracellular routing of an antibody-ricin A chain conjugate.
An immunotoxin (IT) was prepared from monoclonal antibody (MoAb) 115D8 and ricin A chain. MoAb 115D8 is directed against the… 
Highly Cited
1984
Highly Cited
1984
Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors:pokeweed antiviral protein or ricin A chain.
Pokeweed antiviral protein (PAP) and ricin A chain are potent inhibitors of protein synthesis that inactivate eukaryotic 60S… 
Highly Cited
1982
Highly Cited
1982
Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.
The toxic subunit of ricin has been conjugated by a disulfide bound to a monoclonal murine antibody (J-5) specific for the common… 
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