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Ricin A Chain
Known as:
A Chain, Ricin
One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
National Institutes of Health
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Ricin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Endoplasmic Reticulum-Associated Degradation of Ricin A Chain Has Unique and Plant-Specific Features1
A. Di Cola
,
L. Frigerio
,
J. Lord
,
L. Roberts
,
A. Ceriotti
Plant Physiology
2005
Corpus ID: 25721365
Proteins that fail to fold in the endoplasmic reticulum (ER) or cannot find a pattern for assembly are often disposed of by a…
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Highly Cited
1995
Highly Cited
1995
Cell-specific delivery of bacteriophage-encapsidated ricin A chain.
M. Wu
,
W. L. Brown
,
P. Stockley
Bioconjugate chemistry
1995
Corpus ID: 36166045
We have used covalent coupling of deglycosylated ricin A chain (RAC) to the assembly initiation/translational repression RNA stem…
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Highly Cited
1995
Highly Cited
1995
Ricin A Chain Can Be Chemically Cross-linked to the Mammalian Ribosomal Proteins L9 and L10e (*)
C. Vater
,
L. Bartle
,
J. Leszyk
,
J. Lambert
,
V. Goldmacher
Journal of Biological Chemistry
1995
Corpus ID: 24655847
Indirect immunofluorescence studies revealed that when fixed, permeabilized cultured human cells were incubated with ricin A…
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Highly Cited
1993
Highly Cited
1993
Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells.
R. Wales
,
L. Roberts
,
J. Lord
Journal of Biological Chemistry
1993
Corpus ID: 19624977
An Escherichia coli expression system was used to produce recombinant ricin A chain (RTA) and RTA modified either by the addition…
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Highly Cited
1992
Highly Cited
1992
Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography.
Y. Kim
,
J. Robertus
Protein Engineering
1992
Corpus ID: 8679104
Active site residues of ricin A chain were analyzed by site-directed mutagenesis and X-ray diffraction to help assess their roles…
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Highly Cited
1989
Highly Cited
1989
Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild‐type and mutant polypeptides.
M. May
,
M. Hartley
,
L. Roberts
,
P. Krieg
,
R. Osborn
,
J. Lord
EMBO Journal
1989
Corpus ID: 20091280
When recombinant ricin A chain transcripts are translated in a rabbit reticulocyte lysate the ribosomes are rapidly inactivated…
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Highly Cited
1989
Highly Cited
1989
Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates.
S. Pincus
,
K. Wehrly
,
B. Chesebro
Journal of Immunology
1989
Corpus ID: 23104139
mAb 907 is directed against the envelope protein of the HIV. The epitope recognized by this antibody is expressed in moderate…
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1988
1988
Endocytosis and intracellular routing of an antibody-ricin A chain conjugate.
J. Calafat
,
C. Molthoff
,
H. Janssen
,
J. Hilkens
Cancer Research
1988
Corpus ID: 2802518
An immunotoxin (IT) was prepared from monoclonal antibody (MoAb) 115D8 and ricin A chain. MoAb 115D8 is directed against the…
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Highly Cited
1984
Highly Cited
1984
Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors:pokeweed antiviral protein or ricin A chain.
S. Ramakrishnan
,
L. Houston
Cancer Research
1984
Corpus ID: 1034908
Pokeweed antiviral protein (PAP) and ricin A chain are potent inhibitors of protein synthesis that inactivate eukaryotic 60S…
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Highly Cited
1982
Highly Cited
1982
Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.
V. Raso
,
J. Ritz
,
M. Basala
,
S. Schlossman
Cancer Research
1982
Corpus ID: 13892389
The toxic subunit of ricin has been conjugated by a disulfide bound to a monoclonal murine antibody (J-5) specific for the common…
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