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Ribosomal Protein S6 Kinase Alpha-1, human

Known as: p90S6K, MAPK-Activated Protein Kinase 1a, Ribosomal S6 Kinase 1 
Ribosomal protein S6 kinase alpha-1 (735 aa, ~83 kDa) is encoded by the human RPS6KA1 gene. This protein is involved in MAPK signaling and regulation… 
National Institutes of Health

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8 relations
Enzyme GenePhosphorylationPhosphotransferasesProtein phosphorylation

Papers overview

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2018
2018
Effect of Chronic Alcohol Abuse on Anabolic and Catabolic Signaling Pathways in Human Skeletal Muscle
BACKGROUND Animal studies showed that alcoholic myopathy is characterized by the reduction in myofiber cross-sectional area (CSA… 
2016
2016
Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved
Polychlorinated biphenyls (PCBs) are a class of organic pollutants that have been linked to pancreatic disease. However, their… 
2015
2015
IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils
IL-5 is a major therapeutic target to reduce eosinophilia. However, all of the eosinophil-activating cytokines, such as IL-5, IL… 
2015
2015
Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion
ABSTRACT Integrins play crucial roles in epithelial adhesion, proliferation, wound healing and cancer. In the epidermis, the… 
2015
2015
Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes
Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein-coupled receptor (GPCR) member of the bombesin receptor family… 
2011
2011
Counter-regulation of cholinesterases: differential activation of PKC and ERK signaling in retinal cells through BChE knockdown.
2009
2009
The PKARIα Subunit of Protein Kinase A Modulates the Activation of p90RSK1 and Its Function*
Previously, we showed that interactions between p90RSK1 (RSK1) and the subunits of type I protein kinase A (PKA) regulate the… 
2008
2008
Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1, 25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling
Differentiation therapy of cancer is being explored as a potential modality for treatment of myeloid leukemia, and derivatives of… 
Highly Cited
1999
Highly Cited
1999
Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry
Mitogen‐activated protein kinase (MAPK) modules, composed of three protein kinases activated by successive phosphorylation, are… 
Highly Cited
1997
Highly Cited
1997
CREB is activated by UVC through a p38/HOG‐1‐dependent protein kinase
Changes in environmental conditions such as the addition of growth factors or irradiation of cells in culture first affect… 
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