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Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.
Progression of mammalian cells through G1 is controlled by the concerted action of protein kinases, the activities of which are modulated in both positive (cyclins) and negative [cyclin-dependent… Expand
Vitamin D and differentiation in cancer
- Elżbieta Gocek, G. P. Studzinski
- Biology, Medicine
- Critical reviews in clinical laboratory sciences
- 1 August 2009
This paper reviews the current understanding of the vitamin D-induced differentiation of neoplastic cells, which results in the generation of cells that acquire near-normal, mature phenotype.… Expand
Retinoblastoma Protein and CCAAT/Enhancer-Binding Protein β Are Required for 1,25-Dihydroxyvitamin D3-Induced Monocytic Differentiation of HL60 Cells
Derivatives of vitamin D (deltanoids) are well known to have the ability to induce differentiation of a variety of malignant cells, including human leukemia cells, but the signaling pathways that… Expand
Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.
- P. Hughes, E. Marcinkowska, Elżbieta Gocek, G. P. Studzinski, G. Brown
- Biology, Medicine
- Leukemia research
- 1 May 2010
Primitive myeloid leukemic cell lines can be driven to differentiate to monocyte-like cells by 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), and, therefore, 1,25(OH)(2)D(3) may be useful in… Expand
Activation of extracellular signal‐regulated kinases (ERKs) defines the first phase of 1,25‐dihydroxyvitamin D3‐induced differentiation of HL60 cells
Activation of ERK1 and ERK2 protein kinases has been implicated in diverse cellular processes, including the control of cell proliferation and cell differentiation (Marshall [ 1995 ] Cell 80:179). In… Expand
MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3
Human myeloid leukemia cells exposed to 1,25-dihydroxyvitamin D3 (1,25D), a major cancer chemopreventive agent, acquire features of normal monocytes and arrest in the G1 phase of the cell cycle, due… Expand
Cooperation between antioxidants and 1,25‐dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP‐1/Egr‐1 pathway
- Q. Wang, Hagar Salman, M. Danilenko, G. P. Studzinski
- Biology, Medicine
- Journal of cellular physiology
- 1 September 2005
Vitamin D derivatives have demonstrated anti‐cancer activity, but their clinical use is precluded by hypercalcemia. Previously, we found that carnosic acid potentiates differentiation of human… Expand
Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases.
- G. P. Studzinski, John A. McLane, M. Uskoković
- Critical reviews in eukaryotic gene expression
The physiological form of vitamin D, 1 alpha,25-dihydroxyvitamin D3 (1,25D3) is not only a powerful regulator of calcium homeostasis but also a hormone with important roles in cell growth and… Expand
Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by "MEK-specific" inhibitors PD 098059 and U0126 in differentiating HL60 cells.
Determination of the involvement of MAP kinase cascades in signaling cell growth or differentiation is aided by the use of the inhibitors PD 098059 [2-(2'-amino-3'-methoxyphenyl)oxananphthalen-4-one]… Expand
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells.
Differentiation therapy for neoplastic diseases has potential for supplementing existing treatment modalities but its implementation has been slow. One of the reasons is the lack of full… Expand