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Ribonucleotide Reductase Inhibitor

Any substance that inhibits ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleotide… Expand
National Institutes of Health

Papers overview

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2008
2008
SummaryPurpose: This Phase I dose escalation study was based on the hypothesis that the addition of 3-aminopyridine-2… Expand
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2007
2007
Triapine, a potent inhibitor of ribonucleotide reductase, has demonstrated anti-leukemia activity in pre-clinical models. We… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP; Triapine; Vion Pharmaceuticals Inc, New Haven, CT) is a potent… Expand
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2004
2004
The Snf1/AMP-activated kinases are involved in a wide range of stress responses in eukaryotic cells. We discovered a novel role… Expand
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2003
2003
PURPOSE A Phase I study in patients with advanced cancer was conducted to determine the safety, pharmacokinetics, and maximum… Expand
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2003
2003
In a phase I study, 24 patients with refractory leukemia received Triapine, a novel ribonucleotide reductase (RR) inhibitor, as a… Expand
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2002
2002
In this study, we investigated the influence of Bcl-2 overexpression on the radiosensitizing potential of Didox (DX; 3,4… Expand
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Highly Cited
2001
Highly Cited
2001
The evolutionarily conserved protein kinases Mec1 and Rad53 are required for checkpoint response and growth. Here we show that… Expand
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Highly Cited
1997
Highly Cited
1997
Ribonucleotide reductases catalyze the formation of deoxyribonucleotides by the reduction of the corresponding ribonucleotides… Expand
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Highly Cited
1990
Highly Cited
1990
The new deoxycytidine analogue 2',2'-difluorodeoxycytidine (dFdC) is a specific inhibitor of DNA synthesis that has marked… Expand
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