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Ribonucleotide Reductase Inhibitor

Any substance that inhibits ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleotide… Expand
National Institutes of Health

Papers overview

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2008
2008
SummaryPurpose: This Phase I dose escalation study was based on the hypothesis that the addition of 3-aminopyridine-2… Expand
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Highly Cited
2008
Highly Cited
2008
Triapine is a potent ribonucleotide reductase (RR) inhibitor that depletes intracellular deoxyribonculeotide pools, especially… Expand
Highly Cited
2007
Highly Cited
2007
Triapine, a potent inhibitor of ribonucleotide reductase, has demonstrated anti-leukemia activity in pre-clinical models. We… Expand
Highly Cited
2004
Highly Cited
2004
PURPOSE 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP; Triapine; Vion Pharmaceuticals Inc, New Haven, CT) is a potent… Expand
Highly Cited
2003
Highly Cited
2003
PURPOSE A Phase I study in patients with advanced cancer was conducted to determine the safety, pharmacokinetics, and maximum… Expand
Highly Cited
2003
Highly Cited
2003
In a phase I study, 24 patients with refractory leukemia received Triapine, a novel ribonucleotide reductase (RR) inhibitor, as a… Expand
Highly Cited
2002
Highly Cited
2002
In this study, we investigated the influence of bcl-2 overexpression on the radiosensitizing potential of Didox (DX; 3,4… Expand
Highly Cited
2001
Highly Cited
2001
The evolutionarily conserved protein kinases Mec1 and Rad53 are required for checkpoint response and growth. Here we show that… Expand
Highly Cited
1997
Highly Cited
1997
Ribonucleotide reductases catalyze the formation of deoxyribonucleotides by the reduction of the corresponding ribonucleotides… Expand
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Highly Cited
1990
Highly Cited
1990
The new deoxycytidine analogue 2',2'-difluorodeoxycytidine (dFdC) is a specific inhibitor of DNA synthesis that has marked… Expand