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Ribonucleotide Reductase Inhibitor
Any substance that inhibits ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleotide…
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National Institutes of Health
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Ribonucleotide Reductase Inhibitors [MoA]
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer
R. Stauber
,
S. Knauer
,
+11 authors
O. Krämer
OncoTarget
2011
Corpus ID: 14495222
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant neoplasm and more than 50% of patients…
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2008
2008
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes.
Yan Sergerie
,
G. Boivin
Antiviral Research
2008
Corpus ID: 35627533
2006
2006
Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells
N. Raje
,
Santhosh K. P. Kumar
,
+10 authors
K. Anderson
British Journal of Haematology
2006
Corpus ID: 34497940
Ribonucleotide reductase (RR) is the enzyme that catalyses the rate‐limiting step in DNA synthesis, the production of…
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2005
2005
Inactivation of Ku-Mediated End Joining Suppresses mec1Δ Lethality by Depleting the Ribonucleotide Reductase Inhibitor Sml1 through a Pathway Controlled by Tel1 Kinase and the Mre11 Complex
Y. Corda
,
Sang Eun Lee
,
+5 authors
V. Géli
Molecular and Cellular Biology
2005
Corpus ID: 23015166
ABSTRACT RAD53 and MEC1 are essential Saccharomyces cerevisiae genes required for the DNA replication and DNA damage checkpoint…
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2004
2004
Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human…
Z. Horváth
,
T. Höchtl
,
+4 authors
T. Tihan
Cancer Chemotherapy and Pharmacology
2004
Corpus ID: 7953380
PurposeRibonucleotide reductase (RR) is the rate-limiting enzyme of de novo DNA synthesis and has been shown to be upregulated…
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2000
2000
Enhancement of hemoglobin and F‐cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with…
W.E. Iyamu
,
S. Adunyah
,
+4 authors
E. Turner
American journal of hematology/oncology
2000
Corpus ID: 25251380
Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F‐cells. Fetal…
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1996
1996
Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease
C. Brandt
,
B. Spencer
,
P. Imesch
,
M. Garneau
,
R. Déziel
Antimicrobial Agents and Chemotherapy
1996
Corpus ID: 35657060
The ribonucleotide reductase (RR) of herpes simplex virus type 1 (HSV-1) is an important virulence factor, being required for…
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1994
1994
Transgenic mouse model of pharmacologic induction of fetal hemoglobin: Studies using a new ribonucleotide reductase inhibitor, didox
B. Pace
,
B. Pace
,
H. Elford
,
G. Stamatoyannopoulos
American journal of hematology/oncology
1994
Corpus ID: 32162460
Evaluation of pharmacologic agents that stimulate fetal hemoglobin production has been done mainly in baboons and macaques. We…
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Review
1993
Review
1993
Potential for combined therapy with 348u87, a ribonucleotide reductase inhibitor, and acyclovir as treatment for acyclovir‐resistant herpes simplex virus infection
S. Safrin
,
S. Safrin
,
T. Schacker
,
J. Delehanty
,
E. Hill
,
L. Corey
Journal of Medical Virology
1993
Corpus ID: 27815660
Inhibitors of the ribonucleotide reductase of herpes simplex viruses (HSV) potentiate the activity of acyclovir in vitro and in…
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1993
1993
Topical treatment of infection with acyclovir-resistant mucocutaneous herpes simplex virus with the ribonucleotide reductase inhibitor 348U87 in combination with acyclovir
S. Safrin
,
T. Schacker
,
J. Delehanty
,
E. Hill
,
L. Corey
Antimicrobial Agents and Chemotherapy
1993
Corpus ID: 40774211
The thiocarbonohydrazone 348U87 inactivates herpes simplex virus ribonucleotide reductase and potentiates the activity of…
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