FAQ

Ribonucleoside-Diphosphate Reductase Subunit M2 B

Known as: EC 1.17.4.1, p53R2, p53-Inducible Ribonucleotide Reductase Small Subunit 2 Homolog 
Ribonucleoside-diphosphate reductase subunit M2 B (351 aa, ~41 kDa) is encoded by the human RRM2B gene. This protein plays a role in the metabolism… (More)

Topic mentions per year

Topic mentions per year

2002-2017
012320022017

Related topics

Related topics

12 relations
Cell ProliferationDNA RepairDNA ReplicationDrug resistance
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Narrower (1)

RRM1 protein, human

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
Ribonucleoside-Diphosphate Reductase Subunit M2 B
Drug resistance
DNA Repair
Cell Proliferation
DNA Replication
regulatory proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer.
Overexpression of ribonucleotide reductase M2 (hRRM2) and p53-dependent RR small subunit (p53R2) has been correlated with tumor… (More)
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2009
2009
Ribonucleotide reductase small subunit p53R2 promotes oral cancer invasion via the E-cadherin/beta-catenin pathway.
The p53-inducible p53R2 gene has been isolated and shown to play a crucial role in DNA repair and synthesis after DNA damage… (More)
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2008
2008
Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells.
p53R2 is a p53-inducible ribonucleotide reductase that contributes to DNA repair by supplying deoxynucleotide triphosphate pools… (More)
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2007
2007
Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma.
Chemoradiation therapy (CRT), a combination of X-ray irradiation and anticancer agents as a radiosensitizer, has been found to be… (More)
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2006
2006
Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells.
PURPOSE Previous gene transfection studies have shown that the accumulation of human ribonucleotide reductase small subunit M2… (More)
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2006
2006
Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma.
PURPOSE The p53 gene and its family are important factors for carcinogenesis, prognosis, and chemoresistance in esophageal… (More)
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2006
2006
Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells
The p53 protein has been implicated in multiple cellular responses related to DNA damage. Alterations in any of these cellular… (More)
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2005
2005
Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells.
The p53R2 gene encodes the ribonucleotide reductase (RR) small subunit 2 homologue, and is induced by several stress signals… (More)
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2004
2004
In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.
p53R2 is a newly identified subunit of ribonucleotide reductase (RR) and plays a crucial role in supplying precursors for DNA… (More)
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2002
2002
Expression and mutation analyses of P53R2, a newly identified p53 target for DNA repair in human gastric carcinoma.
p53R2, a recently identified putative tumor suppressor located at 8q23.1, encodes a protein with striking similarity to a small… (More)
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