RRM1 protein, human

Known as: Ribonucleoside-Diphosphate Reductase Subunit M1, ribonucleotide reductase M1 polypeptide, human, RRM1 
Ribonucleoside-diphosphate reductase large subunit (792 aa, ~90 kDa) is encoded by the human RRM1 gene. This protein is involved in the conversion of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
PURPOSE We assessed whether chemotherapy selection based on in situ ERCC1 and RRM1 protein levels would improve survival in… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND & AIMS Patients who undergo surgery for pancreatic ductal adenocarcinoma (PDAC) frequently receive adjuvant… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE We evaluated the efficacy of gemcitabine versus gemcitabine and carboplatin in patients with advanced non-small-cell lung… (More)
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Highly Cited
2009
Highly Cited
2009
The identification of molecular markers, useful for therapeutic decisions in pancreatic cancer patients, is crucial for advances… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Overexpression of RRM1 and RRM2 has been associated with gemcitabine resistance. BRCA1 overexpression increases… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND RRM1, the regulatory subunit of ribonucleotide reductase, is involved in carcinogenesis, tumor progression, and the… (More)
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Highly Cited
2007
Highly Cited
2007
Pancreatic cancer is the most lethal of all solid tumors partially because of its chemoresistance. Although gemcitabine is widely… (More)
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Highly Cited
2004
Highly Cited
2004
Ataxia telangiectasia-mutated and Rad3-related (ATR) plays a central role in cell-cycle regulation, transmitting DNA damage… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE RRM1 has important functions in the determination of the malignant phenotype. It controls cell proliferation through… (More)
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Highly Cited
2003
Highly Cited
2003
Lung cancer is the leading cause of cancer-related mortality in the United States. Only 15% of patients with this disease survive… (More)
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