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RRM1 protein, human

Known as: Ribonucleoside-Diphosphate Reductase Subunit M1, ribonucleotide reductase M1 polypeptide, human, RRM1 
Ribonucleoside-diphosphate reductase large subunit (792 aa, ~90 kDa) is encoded by the human RRM1 gene. This protein is involved in the conversion of… 
National Institutes of Health

Related topics

Related topics

16 relations
Cell ProliferationCytoplasmDNA ReplicationEnzyme Gene

Broader (2)

Ribonucleoside-Diphosphate Reductase Subunit M2 BTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP)
RNA binding proteins are involved in many aspects of RNA metabolism. In Trypanosoma brucei, our laboratory has identified two… 
2014
2014
Prognostic significance of BRCA1, ERCC1, RRM1, and RRM2 in patients with advanced non-small cell lung cancer receiving chemotherapy
The aim of this study was to examine the prognostic value of breast cancer susceptibility gene 1 (BRCA1), excision repair cross… 
2014
2014
Expression of ERCC1 and BRCA1 predict the clinical outcome of non-small cell lung cancer in patients receiving platinum-based chemotherapy.
We examined mRNA expression levels of ERCC1, BRCA1, RRM1, and human β-tubulin-III (TUBB3) in non-small-cell lung carcinoma (NSCLC… 
2013
2013
A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy
Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide… 
2012
2012
The irreversible pan-HER inhibitor PF00299804 alone or combined with gemcitabine has an antitumor effect in biliary tract cancer cell lines
SummaryBiliary tract cancer (BTC) is associated with poor survival and unresponsiveness to chemotherapy. Targeted therapies for… 
2010
2010
Histology- and gender-related associations of ERCC1, RRM1, and TS biomarkers in 1,802 patients with NSCLC: Implications for therapy.
7513 Background: Histology-based decision making for non-small cell lung cancer (NSCLC) has recently been advocated. We… 
2010
2010
Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer
The aim of this study was to investigate the influence of histology and site of analysis (primary tumor versus lymph node) on the… 
1993
1993
Herpes simplex virus type 1 ribonucleotide reductase large subunit: regions of the protein essential for subunit interaction and dimerization.
We have constructed a series of random N-terminal deletions of the large subunit (R1) of the herpes simplex virus type 1… 
1993
1993
A solid-phase assay for the binding of peptidic subunit association inhibitors to the herpes simplex virus ribonucleotide reductase large subunit.
The herpes simplex virus (HSV) ribonucleotide reductase is comprised of two nonidentical homodimeric subunits whose association… 
1992
1992
Localization of the antigenic sites and intrinsic protein kinase domain within a 300 amino acid segment of the ribonucleotide reductase large subunit from herpes simplex virus type 2.
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