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Linkage is a phenomenon that correlates the genotypes of loci, rather than the phenotypes of one locus to the genotypes of… Expand It is well known that genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength of… Expand With recent rapid advances in mapping of the human genome, including highly polymorphic and closely linked markers, studies of… Expand To assess evidence for genetic linkage from pedigrees, I developed a limited variance-components approach. In this method… Expand Thirty-nine CEPH (Centre d'Etude du Polymorphisme Humain) families, comprised of 502 individuals, have been typed for the HLA… Expand Linkage disequilibrium mapping in isolated populations provides a powerful tool for fine structure localization of disease genes… Expand Simple single-gene disorders in humans can be genetically mapped by using traditional methods of linkage analysis and… Expand The utility of incompletely linked, selectively neutral, multiallelic markers for tracing the transmission of associated genes is… Expand 1. All members of 33 families in which two or more sibs have insulin‐dependent diabetes mellitus (IDDM) were HLA‐typed. The… Expand This paper examines the theory of the evolution of increased recombination between two loci subjected to interactive selection in… Expand