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Robust relationship inference in genome-wide association studies
A rapid algorithm for relationship inference using high-throughput genotype data typical of GWAS that allows the presence of unknown population substructure and performs relationship inference on millions of pairs of individuals in a matter of minutes, dozens of times faster than the most efficient existing algorithm. Expand
Discovery and Refinement of Loci Associated with Lipid Levels
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Expand
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D,Expand
Early-onset stroke and vasculopathy associated with mutations in ADA2.
Loss-of-function mutations in CECR1 were associated with a spectrum of vascular and inflammatory phenotypes, ranging from early-onset recurrent stroke to systemic vasculopathy or vasculitis, and were prevented by coinjection with nonmutated (but not with mutated) human C ECR1. Expand
Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses
Across the phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association and the two loci associated with depressive symptoms replicate in an independent depression sample. Expand
Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
A computational strategy, SNP2HLA, to impute classical alleles and amino acid polymorphisms at class I and class II HLA loci and how imputation and association testing at amino acid resolution can facilitate fine-mapping of primary MHC association signals is described. Expand
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. Expand
Common variants associated with plasma triglycerides and risk for coronary artery disease
It is suggested that triglyceride-rich lipoproteins causally influence risk for CAD, and the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. Expand
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease. Expand
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease. Expand