• Publications
  • Influence
Robust relationship inference in genome-wide association studies
We present a rapid algorithm for relationship inference using high-throughput genotype data typical of GWAS that allows the presence of unknown population substructure. Expand
  • 1,035
  • 106
  • PDF
Discovery and Refinement of Loci Associated with Lipid Levels
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary arteryExpand
  • 1,821
  • 88
  • PDF
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D,Expand
  • 940
  • 67
  • PDF
Early-onset stroke and vasculopathy associated with mutations in ADA2.
BACKGROUND We observed a syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic vasculopathy in threeExpand
  • 403
  • 42
  • PDF
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Not Just Wasting Malnutrition is well known in Malawi, including a severe form—kwashiorkor—in which children do not simply waste away, they also suffer edema, liver damage, skin ulceration, andExpand
  • 807
  • 33
  • PDF
Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. The complex genetic structure of the major histocompatibility complex (MHC)Expand
  • 421
  • 33
  • PDF
Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that isExpand
  • 542
  • 33
  • PDF
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
BACKGROUND Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has theExpand
  • 637
  • 23
  • PDF
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated withExpand
  • 610
  • 21
  • PDF
High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoidExpand
  • 477
  • 17
  • PDF