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Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects.
Microscopic examination of individual human lymphocytes embedded in agarose, subjected to electrophoresis and stained with a fluorescent DNA-binding dye, provides a novel way of measuring DNA damageExpand
Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure.
TLDR
Investigation of peripheral lymphocytes of a group of Italian floriculturists exposed to a mixture of pesticides found that in heavy smokers, SCE and CA levels increased significantly by 17% and 54%, respectively, as compared to non-smokers. Expand
Benzene and the genotoxicity of its metabolites. I. Transplacental activity in mouse fetuses and in their dams.
TLDR
Benzene and hydroquinone transplacentally induce micronuclei in fetal liver cells while all other metabolites show weak or negative genotoxicity, although they produce severe cellular toxicity. Expand
Micronuclei in exfoliated urothelial cells and urine mutagenicity in smokers.
TLDR
The micronucleus test was validated in urothelial exfoliated cells obtained from urine samples of cigarette smokers for detecting genotoxic effects produced by mutagens/carcinogens in some human target tissues. Expand
Genotoxicity of two metabolites of benzene: phenol and hydroquinone show strong synergistic effects in vivo.
TLDR
It was shown that the observed joint effect was significantly higher than additive interaction, and was close to multiplicative interaction, bringing further support to the hypothesis that the toxic and genotoxic effects of benzene are produced by several metabolites acting synergistically. Expand
Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect.
TLDR
The effect of age on basal frequency of micronucleated cells clearly emerges in the present study: both controls and exposed show an increase in MN frequency due to age, correlated with a higher sensitivity to breaks, rearrangements or aneuploidogenic events of circulating lymphocytes in aged people. Expand
Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program.
TLDR
The yeast tests supplement the bacterial tests for detecting agents that act via radical formation, antibacterial drugs, and other chemicals interfering with chromosome segregation and recombination processes. Expand
Increased mutagenicity of chromium compounds by nitrilotriacetic acid.
TLDR
No gene reversions in five strains of Salmonella typhimurium, no forward gene mutations in Schizosaccharomyces pombe P1, and no mitotic gene conversions at two loci in SacCharomyces cerevisiae D4 were induced by NTA and NIDA, independently of the presence of rat liver metabolic activation. Expand
Correlations between 15 polycyclic aromatic hydrocarbons (PAH) and the mutagenicity of the total PAH fraction in ambient air particles in La Spezia (Italy).
TLDR
Of the 15 PAH considered in this study the amounts of cyclopental[c,d]pyrene (CPP) correlated best with mutagenicity, and the role of CPP in contributing to the indirect Mutagenicity of urban air PAH samples is discussed. Expand
Two years' air mutagenesis monitoring in a northwestern rural area of Italy with an industrial plant.
TLDR
Results show that the mutagenicity of air particulate matter reaches maximum values in the cold months and is not dependent on plant activities, and a correlation analysis betweenmutagenicity data and number of vehicles seems to indicate traffic emissions as the main source of mutagens. Expand
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