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Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects.
Microscopic examination of individual human lymphocytes embedded in agarose, subjected to electrophoresis and stained with a fluorescent DNA-binding dye, provides a novel way of measuring DNA damageExpand
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Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure.
The induction of sister chromatid exchanges (SCE), structural chromosome aberrations (CA) or micronuclei (MN) was investigated in peripheral lymphocytes of a group of Italian floriculturists exposedExpand
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Benzene and the genotoxicity of its metabolites. I. Transplacental activity in mouse fetuses and in their dams.
Benzene and some of its metabolites (hydroquinone, phenol, catechol, 1,2,4-benzenetriol, p-benzoquinone, o,o'-biphenol, p,p'-biphenol) have been tested for their capability to induce micronuclei inExpand
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Micronuclei in exfoliated urothelial cells and urine mutagenicity in smokers.
The use of the micronucleus test on human exfoliated cells has recently been proposed (Stich et al., 1983a) for detecting genotoxic effects produced by mutagens/carcinogens in some human targetExpand
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Genotoxicity of two metabolites of benzene: phenol and hydroquinone show strong synergistic effects in vivo.
Possible interactions between hydroquinone (HQ) and phenol (PHE), 2 known benzene metabolites, in inducing micronuclei in mouse bone marrow cells were investigated. HQ and PHE administered alone gaveExpand
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Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect.
This work is part of a research project on 2 groups of tannery workers (i.e., workers employed in the tanning process and those employed in the finishing department), and 2 control groups consistingExpand
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Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program.
The yeast Saccharomyces cerevisiae is a unicellular fungus that can be cultured as a stable haploid or a stable diploid . Diploid cultures can be induced to undergo meiosis in a synchronous fashionExpand
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Increased mutagenicity of chromium compounds by nitrilotriacetic acid.
Nitrilotriacetic acid trisodium salt (NTA), which is a substitute for polyphosphates in household laundry detergents, and N-nitrosoiminodiacetic acid (NIDA), a derivative of NTA produced byExpand
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Correlations between 15 polycyclic aromatic hydrocarbons (PAH) and the mutagenicity of the total PAH fraction in ambient air particles in La Spezia (Italy).
Airborne particulate matter has been monitored 4 times a month for 1 year (1988) in the city of La Spezia (Italy). The polycyclic aromatic hydrocarbon (PAH) fractions were extracted, purified andExpand
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Comparative studies by comet test and SCE analysis in human lymphocytes from 200 healthy subjects.
The comet test (single cell gel electrophoresis, SCGE) appears to be a promising tool to estimate DNA damage at the single cell level and it provides information on the presence of damage amongExpand
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