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Recombinant Nematode Anticoagulant Protein c2

Known as: rNAPc2 
An 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with… 
National Institutes of Health

Papers overview

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2007
2007
Recombinant nematode anticoagulant protein c2 in non-ST segment elevation acute coronary syndrome and beyond.
Patients with acute coronary syndromes (ACS) have high recurrent ischemic event rates despite management with current guideline… 
2006
2006
Progressive tissue injury in burns is reduced by rNAPc2.
2006
2006
Endotoxaemia induces resistance to activated protein C in healthy humans
Systemic inflammation activates the tissue factor/factor VIIa complex (TF/FVIIa), leading to a procoagulant state, which may be… 
Review
2005
Review
2005
Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex.
Recent developments in the field of haemostasis and thrombosis highlighted the crucial role of the tissue factor/factor VIIa… 
2004
2004
Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin‐10 response in human endotoxemia
Summary.  The tissue factor–factor (F)VIIa complex (TF/FVIIa) is responsible for the initiation of blood coagulation under both… 
Highly Cited
2004
Highly Cited
2004
Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.
BACKGROUND Anticoagulants have gained increasing attention for the treatment of sepsis. Inhibition of the tissue factor (TF… 
2003
2003
Pharmacokinetics and anticoagulant properties of the factor VIIa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man
Summary Recombinant Nematode Anticoagulant Protein c2 (rNAPc2) is a potent (Ki=10 pM), inhibitor of the factor VIIa/tissue factor… 
2002
2002
Recombinant Nematode Anticoagulant Protein c2, a Novel Inhibitor of Tissue Factor-Factor VIIa Activity, Abrogates Endotoxin-Induced Coagulation in Chimpanzees
Summary Systemic activation of coagulation leading to disseminated intravascular coagulation (DIC) is an important feature in… 
Review
2002
Review
2002
Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: from unique mechanism to a promising new clinical anticoagulant.
1999
1999
Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2.
Nematode anticoagulant proteins (NAPs) from the hematophagous nematode Ancylostoma caninum inhibit blood coagulation with… 
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