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A positive fluid balance is associated with a worse outcome in patients with acute renal failure
IntroductionDespite significant improvements in intensive care medicine, the prognosis of acute renal failure (ARF) remains poor, with mortality ranging from 40% to 65%. The aim of the present… Expand
On-ward participation of a hospital pharmacist in a Dutch intensive care unit reduces prescribing errors and related patient harm: an intervention study
IntroductionPatients admitted to an intensive care unit (ICU) are at high risk for prescribing errors and related adverse drug events (ADEs). An effective intervention to decrease this risk, based on… Expand
Attributable mortality of ventilator-associated pneumonia.
- A. D. de Pont
- The Lancet. Infectious diseases
Extracorporeal treatment of intoxications
- A. D. de Pont
- Current opinion in critical care
- 1 December 2007
Purpose of reviewThe purpose of this article is to provide the critical care clinician with a comprehensive review of the indications for extracorporeal elimination of toxic substances, to summarize… Expand
The influence of rewarming after therapeutic hypothermia on outcome after cardiac arrest.
INTRODUCTION Treatment with hypothermia has been shown to improve outcome after cardiac arrest (CA). Current consensus is to rewarm at 0.25-0.5 °C/h and avoid fever. The aim of this study was to… Expand
Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
Spontaneous hypothermia on intensive care unit admission is a predictor of unfavorable neurological outcome in patients after resuscitation: an observational cohort study
- A. W. den Hartog, A. D. de Pont, L. B. Robillard, J. Binnekade, M. Schultz, J. Horn
- Critical care
- 23 June 2010
IntroductionA large number of patients resuscitated for primary cardiac arrest arrive in the intensive care unit (ICU) with a body temperature < 35.0°C. The aim of this observational cohort study was… Expand
Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study
IntroductionRecombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction… Expand
Anticoagulant properties of drotrecogin alfa (activated) during hemofiltration in patients with severe sepsis
In a retrospective study among 35 severely septic patients treated with drotrecogin alfa (activated) (DrotAA) and renal replacement therapy (RRT), Camporota and colleagues demonstrated that the… Expand
MARS treatment in posthepatectomy liver failure
- M. van de Kerkhove, K. P. de Jong, A. Rijken, A. D. de Pont, T. V. van Gulik
- Liver international : official journal of the…
- 1 June 2003
Abstract Posthepatectomy liver failure (PHLF) is a dramatic complication following extensive liver resection or liver resection in a compromised liver, leading to death in 80% of cases. Molecular… Expand