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Recombinant Human CD4 Immunoglobulin

Known as: rCD4-IgG 
An immunoconjugate of recombinant CD4 antigen (rCD4) covalently linked to an immunoglobulin G heavy chain with activity against human… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
Combination therapy with recombinant human soluble CD4-immunoglobulin G and zidovudine in patients with HIV infection: a phase I study.
To determine the effect of zidovudine (ZDV) on the pharmacokinetic disposition of recombinant soluble CD4 immunoglobulin G (rCD4… 
1995
1995
Transport of recombinant human CD4-immunoglobulin G across the human placenta: pharmacokinetics and safety in six mother-infant pairs in AIDS clinical trial group protocol 146
Recombinant CD4-immunoglobulin G (rCD4-IgG) is a 98-kDa human immunoglobulin-like protein that is produced by fusing the gp120… 
1993
1993
Effect of a recombinant CD4-IgG on in vitro T helper cell function: data from a phase I/II study of patients with AIDS.
Ten patients with AIDS were enrolled in a phase I/II protocol of recombinant CD4-IgG (rCD4-IgG) treatment. Patients' peripheral… 
1992
1992
Interference of recombinant soluble CD4 immunoglobulin G in flow cytometric measurement of CD4+ lymphocytes.
Recombinant soluble CD4 covalently linked to an immunoglobulin G heavy chain (rCD4-IgG) was evaluated clinically for the… 
1991
1991
Phase 1 study of recombinant human CD4-immunoglobulin G therapy of patients with AIDS and AIDS-related complex
The safety and pharmacokinetics of recombinant CD4-immunoglobulin G (rCD4-IgG) were evaluated in a phase 1 study with dose… 
1991
1991
New Trends in Pharmacokinetics
The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and… 
1991
1991
The Role of Pharmacokinetics and Pharmacodynamics in the Development of Therapeutic Proteins
Since the degree of preclinical work conducted to address safety issues in animals is usually rate limiting to the initiation of… 
1991
1991
Phase1StudyofRecombinant HumanCD4-Immunoglobulin G Therapy ofPatients withAIDSandAIDS-Related Complex
G (rCD4-IgG) wereevaluated ina phase 1study withdoseescalation. Atotal of16patients, 6withAIDSand10withAIDS-related complex, were… 
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