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Update of the Drug Resistance Mutations in HIV-1.
The International AIDS Society-USA (IAS-USA) Drug Resistance Mutations Group reviews new data on HIV-1 drug resistance that have been published or presented at recent scientific meetings to maintain
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
TLDR
There are significant enrichments at different stages of cellular differentiation in the chronic phase of persistent infection according to the viral specificity, which suggests that distinct memory T-cell populations are established in different virus infections.
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.
TLDR
In a study of 22 patients successfully treated with HAART for up to 30 months, replication-competent virus was routinely recovered from resting CD4+ T lymphocytes, and generally did not show mutations associated with resistance to the relevant antiretroviral drugs.
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome
TLDR
It is reported here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5′→3′ direction.
Rapid evolution of the neutralizing antibody response to HIV type 1 infection
TLDR
Plasma virus continually and rapidly evolved to escape neutralization, indicating that neutralizing antibody exerts a level of selective pressure that has been underappreciated based on earlier, less comprehensive characterizations.
The Challenge of Finding a Cure for HIV Infection
TLDR
The current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure are discussed.
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.
TLDR
In most HIV-infected patients with prior antiretroviral therapy, the combination of indinavir, zidovudine, and lamivudine reduces levels of HIV RNA to less than 500 copies per milliliter for as long as one year.
Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel.
TLDR
This report provides guidelines for when to initiate antiretroviral therapy, selection of appropriate initial regimens, patient monitoring, when to change therapy, and what regimens to use when changing.
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
TLDR
Partial sequencing of HIV pol revealed no new drug resistance mutations or discernible evolution, providing evidence for viral latency rather than drug failure.
Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel.
TLDR
The availability of new antiretroviral drugs has expanded treatment choices and the importance of adherence, emerging long-term complications of therapy, recognition and management of antireTroviral failure, and new monitoring tools are addressed.
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