Recombinant Brain-Derived Growth Factors

Known as: BDNF, Brain-Derived Neurotrophic Factor 
Recombinant therapeutic agents chemically identical to or similar to endogenous nerve growth factors (neurotrophins) that play vital roles in the… (More)
National Institutes of Health

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BDNF geneBrain-Derived Neurotrophic FactorBrain-Derived Neurotrophic Factor Measurementbrain-derived neurotrophic factor, human

Papers overview

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Highly Cited
2010
Highly Cited
2010
Serum and plasma BDNF levels in major depression: a replication study and meta-analyses.
OBJECTIVES Alterations of BDNF signalling in major depression (MD) are supported by studies demonstrating decreased levels of the… (More)
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Highly Cited
2006
Highly Cited
2006
Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
The ability of exercise to benefit neuronal and cognitive plasticity is well recognized. This study reveals that the effects of… (More)
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Highly Cited
2005
Highly Cited
2005
Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice.
Molecular mechanisms underlying the role of statins in the induction of brain plasticity and subsequent improvement of neurologic… (More)
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Highly Cited
2005
Highly Cited
2005
Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
Drug development research has identified neurotrophic factors as a downstream target of chronic antidepressant treatments. In… (More)
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Review
2003
Review
2003
Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.
Although all cells in the body require energy to survive and function properly, excessive calorie intake over long time periods… (More)
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Highly Cited
2003
Highly Cited
2003
Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways.
Cultured embryonic cortical progenitor cells will mimic the temporal differentiation pattern observed in vivo, producing neurons… (More)
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Review
2002
Review
2002
Exercise: a behavioral intervention to enhance brain health and plasticity
Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly… (More)
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Highly Cited
2002
Highly Cited
2002
Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production.
Treatment of traumatic brain injury (TBI) with bone marrow stromal cells (MSCs) improves functional outcome in the rat. However… (More)
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Highly Cited
2000
Highly Cited
2000
Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease.
Alzheimer's disease is a progressive neurodegenerative disorder of the central nervous system. One pathological characteristic is… (More)
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Highly Cited
1991
Highly Cited
1991
Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF
mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts… (More)
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