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Purification of a new neurotrophic factor from mammalian brain.
TLDR
This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties. Expand
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
TLDR
Mice that develop pathology from non‐mutant human tau, in the absence of other exogenous factors, including β‐amyloid are presented. Expand
Physiology of the neurotrophins.
TLDR
Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system. Expand
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family
TLDR
Taking advantage of sequence identities between NGF and BDNF, a third member of this family of secretory proteins is identified, which is named neurotrophin-3, and a remarkable number of amino acid identities are revealed, including all cys-teine residues. Expand
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.
TLDR
The most primitive neurotrophin genes have been isolated from jawless fishes, a river lamprey and the Atlantic hagfish, and they encode pre-pro-neurotrophins, which may serve the purpose of limiting their range of action. Expand
Molecular cloning and expression of brain-derived neurotrophic factor
TLDR
The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally. Expand
Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth
TLDR
Results indicate that p75NTR modulates in a ligand-dependent fashion the activity of intracellular proteins known to regulate actin assembly, and that axonal outgrowth was retarded in mice carrying a mutation in the p 75NTR gene. Expand
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
TLDR
In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres. Expand
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
TLDR
BRAIN-derived neurotrophic factor seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease. Expand
Glial cells generate neurons: the role of the transcription factor Pax6
TLDR
An important role of Pax6 as intrinsic fate determinant of the neurogenic potential of glial cells is demonstrated and retrovirally mediated Pax6 expression instructs neurogenesis even in astrocytes from postnatal cortex in vitro. Expand
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