brain-derived neurotrophic factor, human

Known as: BDNF, BDNF protein, human, BDNF, human 
Brain-derived neurotrophic factor (247 aa, ~28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the… (More)
National Institutes of Health

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BDNF geneBDNF wt AlleleBrain-Derived Neurotrophic Factor MeasurementCell Proliferation Regulatory Process
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Brain-Derived Neurotrophic Factor

Papers overview

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2014
2014
microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking.
Escalation of voluntary alcohol consumption is a hallmark of alcoholism, but its neural substrates remain unknown. In rats… (More)
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Highly Cited
2011
Highly Cited
2011
Self-amplifying autocrine actions of BDNF in axon development.
A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the… (More)
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2011
2011
Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion.
Previous work in culture has shown that basal forebrain (BF) oligodendrocyte (OLG) lineage cells respond to BDNF by increasing… (More)
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2010
2010
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
OBJECTIVE Recent genome-wide association studies have identified multiple novel loci associated with obesity in Europeans. We… (More)
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Highly Cited
2003
Highly Cited
2003
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.
Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the… (More)
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Highly Cited
2001
Highly Cited
2001
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor.
We examined the biosynthesis and post-translational processing of the brain-derived neurotrophic factor precursor (pro-BDNF) in… (More)
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Highly Cited
1998
Highly Cited
1998
Rapid Alterations of BDNF Protein Levels in the Rat Brain after Focal Ischemia: Evidence for Increased Synthesis and Anterograde Axonal Transport
Cellular localization and tissue levels of BDNF protein were studied using immunocytochemistry and enzyme immunoassay… (More)
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Highly Cited
1998
Highly Cited
1998
Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord.
The infusion of BDNF and NT-3 into Schwann cell (SC) grafts promotes regeneration of brainstem neurones into the grafts placed in… (More)
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Highly Cited
1997
Highly Cited
1997
Brain-derived neurotrophic factor is reduced in Alzheimer's disease.
Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor expression. Consistent with this hypothesis, a… (More)
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1995
1995
Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.
The development and sustenance of specific neuronal populations in the peripheral and central nervous systems are controlled… (More)
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