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Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I*
Findings support that not only CREB but also USF1/USF2 contributes to Ca2+ signal-mediated activation of BDNF-PI through the recognition of an overlapping CRE and USF-binding element.
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions
Valproic acid (VPA) may disrupt a balance between excitatory and inhibitory neuronal activities through its epigenetic effect.
Differential Activation of Brain-derived Neurotrophic Factor Gene Promoters I and III by Ca2+ Signals Evoked vial-type Voltage-dependent andN-Methyl-d-aspartate Receptor Ca2+Channels*
The increase in BDNF mRNA expression induced at high K+ was repressed not only by nicardipine, an antagonist for L-VDCC, but also by dl-amino-5-phosphonovalerate, an antagonists for NMDA-R, which was supported by the effects of antagonists on the Ca2+ influx.
Regulation of neurotrophin‐3 gene transcription by Sp3 and Sp4 in neurons
It is found that an NT‐3 transcript containing EIB is predominantly expressed in cortical neurons which preferentially utilize promoter B, and two tandemly repeated GC‐boxes are required for the transcription.
Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms
Robust stimulation of TrkB autonomously induces delayed BDNF mRNA expression in an activity‐dependent manner in rat cortical neurons, resulting in the stimulation of Arc mRNA expression through endogenously synthesized BDNF, the process being orchestrated by the Ca2+ and ERK/MAPK signaling pathways.
Developmental expression of the SRF co‐activator MAL in brain: role in regulating dendritic morphology
Findings indicate that the MAL‐SRF signaling pathway plays a key role in regulating dendritic morphology in adult brain and cultured cortical neurons.
Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF.
To know the role of repressor element-1 (RE-1)-silencing transcription factor (REST) in activity-dependent gene transcription in neurons, we investigated whether the Ca2+ signal-induced transcription
Deltamethrin, a Pyrethroid Insecticide, Is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons
It is found that deltamethrin, a type II pyrethroid insecticide, was highly effective in inducing BDNF expression in culture and in the rat brain and that it may induce neuronal hyperexcitation if it reaches the brain.
Repression of activity-dependent c-fos and brain-derived neurotrophic factor mRNA expression by pyrethroid insecticides accompanying a decrease in Ca(2+) influx into neurons.
In primary culture of mouse cerebellar granule cells (CGCs), stimulation with veratridine induced c-fos and BDNF mRNA expression accompanying the Ca(2+) influx into neurons, and permethrin inhibited the activity-dependent gene expression in neurons.
Coactivation of secretogranin-II and BDNF genes mediated by calcium signals in mouse cerebellar granule cells.
Sg-II gene is coactivated with BDNF gene in response to the intracellular Ca2+ signals evoked via Ca2 + influx through VDCCs, by a comparison with BD NF and c-fos genes.