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Receptors, Purinergic P2Y2

Known as: Puringergic Receptor P2Y, G-Protein Coupled, 2, Receptors, P2Y2, Receptors, P2U 
A subclass of purinergic P2Y receptors that have a preference for ATP and UTP. The activated P2Y2 receptor acts through a G-PROTEIN-coupled… 
National Institutes of Health

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In BloodP2RY2 geneaspects of radiation effectsphysiological aspects

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P2RY2 protein, human

Papers overview

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Highly Cited
2001
Highly Cited
2001
Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate
Abstract. Extracellular nucleotides induce apoptosis and inhibit growth of colorectal cancer cells. To understand the underlying… 
2000
2000
Evidence that rat hepatocytes co‐express functional P2Y1 and P2Y2 receptors
Previous studies have indicated the expression of multiple P2Y receptors by rat hepatocytes although they have not been… 
Highly Cited
1999
Highly Cited
1999
Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat.
The effects of stimulating P2Y1 or P2Y2 purinoceptors on the endothelium of isolated middle cerebral arteries (MCAs), third-order… 
Highly Cited
1997
Highly Cited
1997
Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways.
Defining the mechanism for regulation of arachidonic acid (AA) release is important for understanding cellular production of AA… 
Highly Cited
1997
Highly Cited
1997
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors
Highly Cited
1997
Highly Cited
1997
Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta.
Extracellular nucleotides, particularly ATP, are involved in the modulation of arterial vasomotricity via P2 purinoceptors… 
1997
1997
Extracellular ATP promotes cellular growth of renal inner medullary collecting duct cells mediated via P2u receptors.
The present study was undertaken to determine whether extracellular adenosine 5'-triphosphate (ATP) promotes cellular… 
Highly Cited
1995
Highly Cited
1995
Site-directed Mutagenesis of P2U Purinoceptors
Two subtypes of G protein-coupled receptors for nucleotides (P2U and P2Y purinoreceptors) contain several conserved positively… 
Highly Cited
1995
Highly Cited
1995
Cloning and expression of the alveolar type II cell P2u-purinergic receptor.
Adenosine triphosphate (ATP) regulates surfactant phospholipid secretion from alveolar type II cells by interacting with P2… 
Highly Cited
1995
Highly Cited
1995
Coexpression of P2Y and P2U receptors on aortic endothelial cells. Comparison of cell localization and signaling pathways.
Depending on the vascular bed considered, the actions of ATP on the endothelium are mediated by either P2Y or P2U receptors. The… 
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