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Receptors, Purinergic P2Y2

Known as: Puringergic Receptor P2Y, G-Protein Coupled, 2, Receptors, P2Y2, Receptors, P2U 
A subclass of purinergic P2Y receptors that have a preference for ATP and UTP. The activated P2Y2 receptor acts through a G-PROTEIN-coupled… 
National Institutes of Health

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In BloodP2RY2 geneaspects of radiation effectsphysiological aspects

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P2RY2 protein, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Mice lacking P2Y2 receptors have salt‐resistant hypertension and facilitated renal Na+ and water reabsorption
Extracellular nucleotides (e.g., ATP) regulate many physiological and pathophysiological pro‐cesses through activation of… 
Highly Cited
2003
Highly Cited
2003
Differential Properties of Astrocyte Calcium Waves Mediated by P2Y1 and P2Y2 Receptors
Intercellular spread of Ca2+ waves is the primary manifestation of cell-to-cell communication among astrocytes. Ca2+ waves… 
Highly Cited
1998
Highly Cited
1998
Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C*
We examined downstream signaling events that followed the exposure of PC12 cells to extracellular ATP and UTP, and we compared… 
Highly Cited
1998
Highly Cited
1998
Cystic Fibrosis Transmembrane Regulator-independent Release of ATP
The cystic fibrosis (CF) transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl− channel that is defective in CF cells. It… 
Highly Cited
1996
Highly Cited
1996
Enteric Glia Exhibit P2U Receptors that Increase Cytosolic Calcium by a Phospholipase C‐Dependent Mechanism
Abstract: Calcium signaling in fura‐2 acetoxymethyl ester‐loaded enteric glia was investigated in response to neuroligands… 
Highly Cited
1995
Highly Cited
1995
Site-directed Mutagenesis of P2U Purinoceptors
Two subtypes of G protein-coupled receptors for nucleotides (P2U and P2Y purinoreceptors) contain several conserved positively… 
Highly Cited
1995
Highly Cited
1995
Cloning and expression of the alveolar type II cell P2u-purinergic receptor.
Adenosine triphosphate (ATP) regulates surfactant phospholipid secretion from alveolar type II cells by interacting with P2… 
Highly Cited
1993
Highly Cited
1993
Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits.
It has been shown that nitric oxide (NO) is synthesized in the central nervous system as well as in vascular endothelial cells… 
Highly Cited
1993
Highly Cited
1993
Heterogeneity of ATP receptors in aortic endothelial cells. Involvement of P2y and P2u receptors in inositol phosphate response.
Extracellular ATP plays an important role in the regulation of prostacyclin and nitric oxide release from vascular endothelial… 
Highly Cited
1993
Highly Cited
1993
Increases in intracellular calcium via activation of an endogenous P2‐purinoceptor in cultured CHO‐K1 cells
1 Increases in intracellular calcium ([Ca2+]i) were measured in Chinese hamster cultured ovary cells (clone, CHO‐K1), by use of… 
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