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Receptors, Purinergic P2Y2

Known as: Puringergic Receptor P2Y, G-Protein Coupled, 2, Receptors, P2Y2, Receptors, P2U 
A subclass of purinergic P2Y receptors that have a preference for ATP and UTP. The activated P2Y2 receptor acts through a G-PROTEIN-coupled… Expand
National Institutes of Health

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In BloodP2RY2 geneaspects of radiation effectsphysiological aspects

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P2RY2 protein, human

Papers overview

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2011
2011
Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells.
In blood vessels, stimulation of the vascular endothelium by the Ca(2+)-mobilizing agonist ATP initiates a number of cellular… Expand
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Highly Cited
2007
Highly Cited
2007
Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption.
Extracellular nucleotides (e.g., ATP) regulate many physiological and pathophysiological processes through activation of… Expand
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2005
2005
Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin
The distribution of P2Y2 receptor-immunoreactive (ir) neurons and fibers and coexistence of P2Y2 with P2X2 and P2X3 receptors… Expand
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Highly Cited
2003
Highly Cited
2003
Differential Properties of Astrocyte Calcium Waves Mediated by P2Y1 and P2Y2 Receptors
Intercellular spread of Ca2+ waves is the primary manifestation of cell-to-cell communication among astrocytes. Ca2+ waves… Expand
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Highly Cited
2003
Highly Cited
2003
P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages.
ATP receptors present on rat alveolar macrophages (NR8383 cells) were identified by recordings of membrane current, measurements… Expand
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2001
2001
Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate
Abstract. Extracellular nucleotides induce apoptosis and inhibit growth of colorectal cancer cells. To understand the underlying… Expand
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Highly Cited
1999
Highly Cited
1999
Regulation of epidermal homeostasis through P2Y2 receptors.
1. Previous studies have indicated a role for extracellular ATP in the regulation of epidermal homeostasis. Here we have… Expand
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Highly Cited
1998
Highly Cited
1998
Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C*
We examined downstream signaling events that followed the exposure of PC12 cells to extracellular ATP and UTP, and we compared… Expand
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Highly Cited
1997
Highly Cited
1997
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors
Adenine and uridine nucleotide-promoted inositol phosphate accumulation was studied in HEK293 cells. Concentration effect curves… Expand
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Highly Cited
1993
Highly Cited
1993
Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits.
It has been shown that nitric oxide (NO) is synthesized in the central nervous system as well as in vascular endothelial cells… Expand
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