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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome andExpand
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An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats
Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385–base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in theExpand
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An epididymis-specific β-defensin is important for the initiation of sperm maturation
Although the role of the epididymis, a male accessory sex organ, in sperm maturation has been established for nearly four decades, the maturation process itself has not been linked to a specificExpand
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Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel, mutations of which cause cystic fibrosis, a disease characterized by defective Cl− and HCO3− transport. Although >95%Expand
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Distribution and Regulation of ENaC Subunit and CFTR mRNA Expression in Murine Female Reproductive Tract
The present study investigated the regional distribution and cyclic changes in the mRNA expression of epithelial Na+ channel (ENaC) subunit and cystic fibrosis transmembrane conductance regulatorExpand
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Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by which these implants improve fractureExpand
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TRAPPC9 Mediates the Interaction between p150Glued and COPII Vesicles at the Target Membrane
Background The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent on microtubules.Expand
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Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmarkExpand
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FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway
Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, theExpand
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Regulation of male fertility by CFTR and implications in male infertility.
BACKGROUND The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with maleExpand
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