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- Influence
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
- Guangwu Guo, X. Sun, +53 authors Zhiming Cai
- Biology, Medicine
- Nature Genetics
- 1 December 2013
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and… Expand
An Antimicrobial Peptide Gene Found in the Male Reproductive System of Rats
Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385–base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the… Expand
An epididymis-specific β-defensin is important for the initiation of sperm maturation
- C. Zhou, Yonglian Zhang, +9 authors H. Chan
- Biology, Medicine
- Nature Cell Biology
- 1 May 2004
Although the role of the epididymis, a male accessory sex organ, in sperm maturation has been established for nearly four decades, the maturation process itself has not been linked to a specific… Expand
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
- Wen Ming Xu, Q. X. Shi, +15 authors H. Chan
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 5 June 2007
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel, mutations of which cause cystic fibrosis, a disease characterized by defective Cl− and HCO3− transport. Although >95%… Expand
Distribution and Regulation of ENaC Subunit and CFTR mRNA Expression in Murine Female Reproductive Tract
- L. Chan, L. Tsang, +4 authors H. Chan
- Biology, Medicine
- The Journal of Membrane Biology
- 15 January 2002
The present study investigated the regional distribution and cyclic changes in the mRNA expression of epithelial Na+ channel (ENaC) subunit and cystic fibrosis transmembrane conductance regulator… Expand
Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by which these implants improve fracture… Expand
TRAPPC9 Mediates the Interaction between p150Glued and COPII Vesicles at the Target Membrane
- Min Zong, Ayano Satoh, +5 authors S. Yu
- Biology, Medicine
- PloS one
- 18 January 2012
Background The transport of endoplasmic reticulum (ER)-derived COPII vesicles toward the ER-Golgi intermediate compartment (ERGIC) requires cytoplasmic dynein and is dependent on microtubules.… Expand
Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark… Expand
FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway
- Xinmei Liu, H. Chan, +13 authors H. Huang
- Biology, Medicine
- Aging cell
- 6 March 2015
Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the… Expand
Regulation of male fertility by CFTR and implications in male infertility.
- H. Chen, Y. Ruan, Wen Ming Xu, J. Chen, H. Chan
- Medicine, Biology
- Human reproduction update
- 1 November 2012
BACKGROUND
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO(3)(-) conducting channel, mutations of which are known to be associated with male… Expand
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