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Receptor, TIE-2

Known as: Angiopoietin Receptor Tie 2, Tek Receptor, Receptor Tie-2, Angiopoietin 
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Background: The signaling events by which lactate instructs endothelial cells to undergo angiogenesis are incompletely resolved… Expand
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Highly Cited
2004
Highly Cited
2004
Background—Angiopoietin (Ang) -1 and -2, their receptor Tie-2, and vascular endothelial growth factor (VEGF) regulate… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES The goal of this research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and… Expand
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Highly Cited
2002
Highly Cited
2002
Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and… Expand
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Highly Cited
2000
Highly Cited
2000
Angiopoietin-1 (Ang1) is a strong apoptosis survival factor for endothelial cells. In this study, the receptor/second messenger… Expand
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Highly Cited
1999
Highly Cited
1999
Recent studies have shown that the angiopoietin-Tie2 system is a predominant regulator of vascular integrity. In this study, we… Expand
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Highly Cited
1998
Highly Cited
1998
Angiopoietin-1 (Ang1) has been recently identified as the major physiological ligand for the tyrosine kinase receptor Tie2 and… Expand
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Highly Cited
1996
Highly Cited
1996
Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases… Expand
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Highly Cited
1996
Highly Cited
1996
TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and early hemopoietic cells and… Expand
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Highly Cited
1994
Highly Cited
1994
The receptor tyrosine kinases (RTKs) expressed on the surface of endothelial cells are likely to play key roles in initiating the… Expand
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