Receptor, TIE-2

Known as: Angiopoietin Receptor Tie 2, Tek Receptor, Receptor Tie-2, Angiopoietin 
A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
0102019942018

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Angiogenesis is a valid target in the treatment of epithelial ovarian cancer. Trebananib inhibits the binding of… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Angiopoietin (Ang) -1 and -2, their receptor Tie-2, and vascular endothelial growth factor (VEGF) regulate… (More)
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Highly Cited
2002
Highly Cited
2002
Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and… (More)
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Highly Cited
2001
Highly Cited
2001
Genetic ablation of angiopoietin-1 (Ang-1) or of its cognate receptor, Tie2, disrupts angiogenesis in mouse embryos. The… (More)
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Highly Cited
1999
Highly Cited
1999
Recent studies have shown that the angiopoietin-Tie2 system is a predominant regulator of vascular integrity. In this study, we… (More)
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Highly Cited
1999
Highly Cited
1999
During development of the vertebrate vascular system essential signals are transduced via protein-tyrosine phosphorylation. Null… (More)
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Highly Cited
1998
Highly Cited
1998
Angiopoietin-1 (Ang1) has been recently identified as the major physiological ligand for the tyrosine kinase receptor Tie2 and… (More)
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Highly Cited
1996
Highly Cited
1996
Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-specific receptor tyrosine kinases… (More)
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Highly Cited
1996
Highly Cited
1996
TIE2 is a receptor-like tyrosine kinase expressed almost exclusively in endothelial cells and early hemopoietic cells and… (More)
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Highly Cited
1994
Highly Cited
1994
The receptor tyrosine kinases (RTKs) expressed on the surface of endothelial cells are likely to play key roles in initiating the… (More)
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