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Ephrin Type-A Receptor 2, human

Known as: EC 2.7.1.112, Tyrosine-Protein Kinase Receptor ECK, Epithelial Cell Receptor Protein Tyrosine Kinase 
Ephrin type-A receptor 2 (976 aa, ~108 kDa) is encoded by the human EPHA2 gene. This protein plays a role in ephrin-A binding, cell-cell signaling… 
National Institutes of Health

Related topics

Related topics

29 relations
Axon GuidanceCell Differentiation processCell ProliferationEPHA2 gene

Broader (2)

EphB2 ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Suppression of Bone Resorption by miR‐141 in Aged Rhesus Monkeys
Aging‐related osteoporosis (OP) is considered a serious public health concern. Approximately 30% of postmenopausal women suffer… 
2016
2016
Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis
ErbB2 signalling, which is amplified by EphA2 binding, is an important therapeutic target for breast cancer. Despite the… 
Highly Cited
2015
Highly Cited
2015
Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition.
Tyrosine kinase inhibitors (TKIs) have become an important therapeutic option for treating several forms of cancer. Gefitinib, an… 
2014
2014
VEGF Increases Paracellular Permeability in Brain Endothelial Cells via Upregulation of EphA2
Neurological disorders are associated with an increase in the permeability of human brain microvascular endothelial cells (HBMEC… 
2013
2013
Receptor Protein Tyrosine Phosphatase-Receptor Tyrosine Kinase Substrate Screen Identifies EphA2 as a Target for LAR in Cell Migration
ABSTRACT Receptor tyrosine kinases (RTKs) exist in equilibrium between tyrosyl-phosphorylated and dephosphorylated states… 
2008
2008
Enhancement in Specific CD8+ T Cell Recognition of EphA2+ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists1
The EphA2 receptor tyrosine kinase is an attractive therapeutic target that is commonly overexpressed on solid tumors, with the… 
2006
2006
A Novel Mechanism for p53 to Regulate Its Target Gene ECK in Signaling Apoptosis
Transcription factor p53 regulates its target genes through binding to DNA consensus sequence and activating the promoters of its… 
2006
2006
Analysis of EphA2 expression and mutant p53 in ovarian carcinoma
The EphA2 tyrosine kinase receptor is frequently overexpressed in ovarian cancer and this feature is predictive of poor clinical… 
2006
2006
Expression of EphA 2 and Ephrin A-1 in Carcinoma of the Urinary Bladder
Purpose: The EphA2 receptor tyrosine kinase is believed to play a role in tumor growth and metastasis.The clinical significance… 
2005
2005
Overexpression of EphA2 gene in invasive human breast cancer and its association with hormone receptor status
9583 Background: EphA2 is a receptor tyrosine kinase for ephrin A-1 that has been implicated in a broad spectrum of functions… 
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