FAQ

Receptor, Endothelin B

Known as: Receptors, Endothelin B, Receptor, Endothelin B [Chemical/Ingredient], Endothelin B Receptors 
Endothelin B receptor (442 aa, ~50 kDa) is encoded by the human EDNRB gene. This protein is involved in vasoconstriction and vasodilation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
010203019892017

Related topics

Related topics

18 relations
EDNRB geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIn Blood
(More)

Narrower (2)

EDNRB protein, humanReceptor, Endothelin B, Type 2

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Receptor, Endothelin B
Plasma membrane
Signal Transduction
physiological aspects
Integral Membrane Proteins
In Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
In spite of their having sufficient immunogenicity, tumor vaccines remain largely ineffective. The mechanisms underlying this… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.
Collecting duct (CD)-derived endothelin-1 (ET-1) inhibits renal Na reabsorption and its deficiency increases blood pressure (BP… (More)
  • figure 1
  • figure 2
  • table 2
  • figure 3
  • table 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension.
BACKGROUND The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors.
The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene.
Recent gene targeting studies have revealed unexpected roles for endothelins in the development of neural crest-derived tissues… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.
The potent vasoconstrictor endothelin-1 (ET-1) is at its highest concentration in the normal human ejaculate and is associated… (More)
  • figure I
  • figure 2
  • figure 3
  • table I
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance.
Hepatic stellate cells are similar to tissue pericytes and have been shown to be contractile. In this study, we examined the… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.
Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice.
Endothelins act on two subtypes of G protein-coupled receptors, termed endothelin-A and endothelin-B receptors. We report a… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.
The characterization and localization of endothelin A (ETA) and endothelin B (ETB) receptors have been determined in tissue… (More)
Is this relevant?