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Failure of atriopeptin II to cause arterial vasodilation in the conscious rat.
The cardiovascular actions of the synthetic natriuretic peptide, atriopeptin II, were examined in conscious unrestrained spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. TheExpand
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Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: involvement of potassium channels.
The vasodilator activity of adenosine has been associated with selective stimulation of A2 receptors. In the present study, the vasorelaxant (VR) activity of an A1-selective agonist, CPAExpand
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Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage.
Delayed cerebral ischemia due to cerebral vasospasm is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Increasing evidence implicates the potentExpand
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Functionally distinct endothelin B receptors in vascular endothelium and smooth muscle.
IRL 1620 (Suc-[Glu9,Ala11,15]-ET-1 (8-21)) (0.1 nM - 1 microM), a novel ETB-selective endothelin (ET) agonist, produced endothelium-dependent relaxations in precontracted rabbit mesenteric artery (2Expand
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Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
The potent vasoconstrictor peptide, endothelin-1 (ET-1), has been implicated in the pathophysiology of cerebral vasospasm that occurs after subarachnoid hemorrhage (SAH). This peptide is synthesizedExpand
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Selective Adenosine-2 Agonist Produces Both Direct and Reflex Tachycardia in Normotensive Rats
Summary: Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-foldExpand
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Effects of fenoldopam on regional vascular resistance in conscious spontaneously hypertensive rats.
The effects of fenoldopam, a selective dopamine-1 agonist, on regional blood flow and vascular resistance were examined in conscious unrestrained spontaneously hypertensive rats (SHR). Rats wereExpand
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Differential responsiveness of conduit and resistance coronary arteries to endothelin A and B receptor stimulation in anesthetized dogs.
The effects of endothelin-1 (ET-1), an ET(A)/ETB-receptor agonist, and IRL 1620, a potent and selective ETB-receptor agonist, were assessed on left circumflex coronary artery diameterExpand
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Pharmacologic Characterization of an EndothelinA (ETA) Receptor Antagonist in Conscious Rats
Summary: The present experiments describe the endothelin-1 (ET-1) antagonist activity of BQ123 (cyclic D-Asp–L-Pro–D-Val–L-Leu–D-Trp) in conscious Sprague–Dawley (SD) rats, and we also examined theExpand
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Rat atriopeptin III alters hypothalamic neuronal activity
The effect of pressure application of rat atriopeptin III on extracellularly recorded action potentials of 39 hypothalamic neurons was studied in chloral hydrate-anesthetized male rats. Thirteen ofExpand
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