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Failure of atriopeptin II to cause arterial vasodilation in the conscious rat.
The cardiovascular actions of the synthetic natriuretic peptide, atriopeptin II, were examined in conscious unrestrained spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. The… Expand
Demonstration of vasorelaxant activity with an A1-selective adenosine agonist in porcine coronary artery: involvement of potassium channels.
- L. A. Merkel, R. Lappe, L. M. Rivera, B. Cox, Mark H. Perrone
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 February 1992
The vasodilator activity of adenosine has been associated with selective stimulation of A2 receptors. In the present study, the vasorelaxant (VR) activity of an A1-selective agonist, CPA… Expand
Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage.
Delayed cerebral ischemia due to cerebral vasospasm is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Increasing evidence implicates the potent… Expand
Functionally distinct endothelin B receptors in vascular endothelium and smooth muscle.
- S. Shetty, T. Okada, R. Webb, D. DelGrande, R. Lappe
- Biology, Medicine
- Biochemical and biophysical research…
- 15 March 1993
IRL 1620 (Suc-[Glu9,Ala11,15]-ET-1 (8-21)) (0.1 nM - 1 microM), a novel ETB-selective endothelin (ET) agonist, produced endothelium-dependent relaxations in precontracted rabbit mesenteric artery (2… Expand
Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
The potent vasoconstrictor peptide, endothelin-1 (ET-1), has been implicated in the pathophysiology of cerebral vasospasm that occurs after subarachnoid hemorrhage (SAH). This peptide is synthesized… Expand
Selective Adenosine-2 Agonist Produces Both Direct and Reflex Tachycardia in Normotensive Rats
Summary: Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold… Expand
Effects of fenoldopam on regional vascular resistance in conscious spontaneously hypertensive rats.
The effects of fenoldopam, a selective dopamine-1 agonist, on regional blood flow and vascular resistance were examined in conscious unrestrained spontaneously hypertensive rats (SHR). Rats were… Expand
Differential responsiveness of conduit and resistance coronary arteries to endothelin A and B receptor stimulation in anesthetized dogs.
The effects of endothelin-1 (ET-1), an ET(A)/ETB-receptor agonist, and IRL 1620, a potent and selective ETB-receptor agonist, were assessed on left circumflex coronary artery diameter… Expand
Pharmacologic Characterization of an EndothelinA (ETA) Receptor Antagonist in Conscious Rats
Summary: The present experiments describe the endothelin-1 (ET-1) antagonist activity of BQ123 (cyclic D-Asp–L-Pro–D-Val–L-Leu–D-Trp) in conscious Sprague–Dawley (SD) rats, and we also examined the… Expand
Rat atriopeptin III alters hypothalamic neuronal activity
The effect of pressure application of rat atriopeptin III on extracellularly recorded action potentials of 39 hypothalamic neurons was studied in chloral hydrate-anesthetized male rats. Thirteen of… Expand