Receptor, Angiotensin, Type 1a

Known as: Angiotensin II Type 1a Receptor, Angiotensin AT1a Receptor, Receptor, Angiotensin II Type 1a 
A subtype of angiotensin receptor found primarily in rodent species that have two type 1 angiotensin receptor genes.
National Institutes of Health

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Receptor, Angiotensin, Type 1

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Highly Cited
2006
Highly Cited
2006
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice.
Blockade of the renin-angiotensin system slows the progression of diabetic nephropathy but fails to abolish the development of… (More)
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Highly Cited
2005
Highly Cited
2005
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Angiotensin II is a multi-functional bioactive peptide and recent reports have suggested that angiotensin II is a proangiogenic… (More)
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Highly Cited
2005
Highly Cited
2005
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a devastating clinical syndrome with a… (More)
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2005
2005
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor.
Although clinical and experimental studies have long suggested a role for the renin-angiotensin system (RAS) in the regulation of… (More)
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Highly Cited
2002
Highly Cited
2002
beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
beta-Arrestins are cytosolic proteins that mediate homologous desensitization of G protein-coupled receptors (GPCRs) by binding… (More)
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2002
2002
Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy.
Although the serious cardiotoxicity of doxorubicin (DOX), a useful chemotherapeutic agent, limits the use of this agent, the… (More)
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Highly Cited
2001
Highly Cited
2001
Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice.
Unilateral ureteral obstruction (UUO) results in tubulointerstitial fibrosis of the affected kidney by stimulating the renin… (More)
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1998
1998
Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias.
BACKGROUND A growing body of evidence has suggested that the renin-angiotensin system plays an important role in the development… (More)
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1998
1998
Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice.
Many lines of evidence have suggested that angiotensin II (AngII) plays an important role in the development of cardiac… (More)
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Highly Cited
1995
Highly Cited
1995
Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia.
Angiotensin (AT) II, the bioactive octapeptide in the renin-angiotensin system that plays a key role in cardiovascular… (More)
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