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Raf Kinase Inhibitor

Any substance that inhibits Raf Kinase, an enzyme active in signal transduction in the Ras pathway. Inhibition of Raf kinase may result in reduced… Expand
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The Raf kinase inhibitor protein 1 (RKIP-1) was the first reported endogenous inhibitor of Raf-1-MEK-ERK/MAPK cascade, by… Expand
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2012
2012
AimRaf kinase inhibitory protein (RKIP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer… Expand
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2011
2011
Raf kinase inhibitor protein (RKIP) interacts with a number of different proteins and regulates multiple signaling pathways. Here… Expand
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2010
2010
BackgroundRaf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival… Expand
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2010
2010
Proteomic approaches have been useful for the identification of aberrantly expressed proteins in complex diseases such as cancer… Expand
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2009
2009
AIM Hepatic stellate cells (HSCs) play an important role in the pathogenesis of liver fibrosis and cirrhosis. Raf kinase… Expand
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Highly Cited
2007
Highly Cited
2007
Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is… Expand
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Review
2004
Review
2004
The metastatic cascade is a complicated process that involves many steps from gain of the metastatic phenotype in the primary… Expand
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Highly Cited
2003
Highly Cited
2003
Feedback inhibition is a fundamental principle in signal transduction allowing rapid adaptation to different stimuli. In… Expand
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Highly Cited
2000
Highly Cited
2000
We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK… Expand
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