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Raf Kinase Inhibitor

Any substance that inhibits Raf Kinase, an enzyme active in signal transduction in the Ras pathway. Inhibition of Raf kinase may result in reduced… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer
AimRaf kinase inhibitory protein (RKIP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer… 
2011
2011
A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.
To identify key proteins involved in the hepatoprotection afforded by schisandrin B (Sch B), we used a proteomic approach to… 
2010
2010
Proteomic analysis of low‐ to high‐grade astrocytomas reveals an alteration of the expression level of raf kinase inhibitor protein and nucleophosmin
Proteomic approaches have been useful for the identification of aberrantly expressed proteins in complex diseases such as cancer… 
Highly Cited
2009
Highly Cited
2009
Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells
Aim: Hepatic stellate cells (HSCs) play an important role in the pathogenesis of liver fibrosis and cirrhosis. Raf kinase… 
2009
2009
Nitric oxide enhances expression of raf kinase inhibitor protein in keratinocytes
Abstract:  Several reports have focused on the potential of nitric oxide (NO) to influence the proliferation and differentiation… 
2009
2009
[Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma].
OBJECTIVE To investigate the relationship between raf kinase inhibitor protein (RKIP), a novel metastasis suppressor gene, and… 
Highly Cited
2007
Highly Cited
2007
Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is… 
2007
2007
Up-RegulationYin Yang 1 Inhibition and Death Receptor 5 Suppressor Raf Kinase Inhibitor Protein via TRAIL-Induced Apoptosis by the Metastatic Regulation of Tumor Cell Sensitivity to
Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is… 
2003
2003
Drug-drug interaction pharmacokinetic study with the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with irinotecan (CPT-11) in patients with solid tumors.
2003
2003
A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors.
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