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Raf Kinase Inhibitor

Any substance that inhibits Raf Kinase, an enzyme active in signal transduction in the Ras pathway. Inhibition of Raf kinase may result in reduced… Expand
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The Raf kinase inhibitor protein 1 (RKIP-1) was the first reported endogenous inhibitor of Raf-1-MEK-ERK/MAPK cascade, by… Expand
2014
2014
Melanoma arising from melanocytes within the choroid is the most frequent primary intraocular neoplasm in adults. It is… Expand
2011
2011
To identify key proteins involved in the hepatoprotection afforded by schisandrin B (Sch B), we used a proteomic approach to… Expand
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2010
2010
Proteomic approaches have been useful for the identification of aberrantly expressed proteins in complex diseases such as cancer… Expand
2010
2010
BackgroundRaf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival… Expand
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2009
2009
Aim: Hepatic stellate cells (HSCs) play an important role in the pathogenesis of liver fibrosis and cirrhosis. Raf kinase… Expand
Highly Cited
2007
Highly Cited
2007
Raf-1 kinase inhibitor protein (RKIP) has been implicated in the regulation of cell survival pathways and metastases, and is… Expand
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Review
2004
Review
2004
  • E. Keller
  • Anti-cancer drugs
  • 2004
  • Corpus ID: 39587900
The metastatic cascade is a complicated process that involves many steps from gain of the metastatic phenotype in the primary… Expand
Highly Cited
2003
Highly Cited
2003
Feedback inhibition is a fundamental principle in signal transduction allowing rapid adaptation to different stimuli. In… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1… Expand
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