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RUNX1T1 wt Allele

Known as: ETO, CBFA2T1 Gene, RUNX1T1 
Human RUNX1T1 wild-type allele is located in the vicinity of 8q22 and is approximately 136 kb in length. This allele, which encodes protein CBFA2T1… 
National Institutes of Health

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8q22CBFA2T1 protein, humanHomo sapiensTranscriptional Regulation

Broader (1)

RUNX1T1 gene

Papers overview

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2015
2015
Promyelocytic Leukemia with No Retinoic Acid Receptor Alpha Abnormality but with RUNX1T1 Insertion to Chromosome 7q: A Classification and Management Dilemma
A case of acute promyelocytic leukemia (APL) with RUNX1T1 insertion to 7q is described and compared to reported cases of APL with… 
2004
2004
Epigenetic regulation of tumor suppressors in t(8:21)-containing AML
The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation… 
2001
2001
[Complex translocation (8;15;21) (q22;p12;q22) in a child with AML-M2 showing de novo appearance of the short form of AML1-MTG8 chimeric mRNA during the course].
A 4-year-old boy admitted with exophthalmos was diagnosed as having acute myeloblastic leukemia with maturation (AML-M2… 
2000
2000
In-Space Deployment Options for Large Space Solar Power Satellites
This research was performed at the Space Systems Design Lab at the Georgia Institute of Technology, Atlanta, GA, with the charter… 
2000
2000
Morphological and cytogenetic changes in therapy-related leukemia developed in a t(8;21)-acute myeloid leukemia (M2) patient: sequential cytogenetic and molecular analyses.
A patient with acute myeloid leukemia (AML)-M2 with t(8;21)(q22;q22) achieved complete remission with remission-induction… 
1999
1999
Association of MTG8 (ETO/CDR), a Leukemia‐related Protein, with Serine/Threonine Protein Kinases and Heat Shock Protein HSP90 in Human Hematopoietic Cell Lines
A proto‐oncogene, MTG8 (ETO/CDR), is disrupted in the t(8;21) translocation associated with acute myeloid leukemia, and the gene… 
1998
1998
Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells
The t(8;21) translocation associated with acute myeloid leukemia (AML) disrupts two genes, the AML1 gene also known as the core… 
1998
1998
Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males.
Obesity has a genetic component and predisposes for the development of type 2 diabetes mellitus. One approach to identifying new… 
1998
1998
Tumourigenicity of MTG8, a leukaemia‐related gene, in concert with v‐Ha‐ras gene in BALB/3T3 cells
The MTG8 (ETO) gene has been identified as the translocation partner of AML1 (PEBP2αB or CBFα2) gene in the AML1/MTG8 (ETO) fused… 
1997
1997
Significance of MTG8 in leukemogenesis.
MTG8 is a counterpart gene of AML1 in acute myeloid leukemia with t(8:21) translocation. Most of the coding region of the MTG8 is… 
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