CBFA2T1 protein, human

Known as: ETO, ETO Protein, Protein ETO 
Protein CBFA2T1 (604 aa, ~68 kDa) is encoded by the human RUNX1T1 gene. This protein plays a role in the regulation of gene transcription.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
05101519462016

Papers overview

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Highly Cited
2012
Highly Cited
2012
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The… (More)
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Highly Cited
2006
Highly Cited
2006
Tumor necrosis factor-alpha (TNF-alpha) is widely known to be involved in physiological and pathophysiological processes of the… (More)
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Highly Cited
2001
Highly Cited
2001
t(8;21) and t(16;21) create two fusion proteins, AML-1-ETO and AML-1-MTG16, respectively, which fuse the AML-1 DNA binding domain… (More)
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Highly Cited
2000
Highly Cited
2000
RAR and AML1 transcription factors are found in leukemias as fusion proteins with PML and ETO, respectively. Association of PML… (More)
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Highly Cited
1999
Highly Cited
1999
The (8;21) translocation, found in 12% of acute myeloid leukemia (AML), creates the chimeric fusion product, AML1-ETO. Previously… (More)
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Highly Cited
1998
Highly Cited
1998
The t(8;21) translocation between two genes known as AML1 and ETO is seen in approximately 12-15% of all acute myeloid leukemia… (More)
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Highly Cited
1998
Highly Cited
1998
t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric protein, acute… (More)
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Highly Cited
1998
Highly Cited
1998
Nuclear receptor corepressor (CoR)-histone deacetylase (HDAC) complex recruitment is indispensable for the biological activities… (More)
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Highly Cited
1998
Highly Cited
1998
AML-1B is a hematopoietic transcription factor that is functionally inactivated by multiple chromosomal translocations in human… (More)
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Highly Cited
1997
Highly Cited
1997
Acute myeloid leukaemia (AMI) is a major haematopoietic malignancy characterized by the proliferation of a malignant clone of… (More)
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