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RUNX1/RUNX1T1 Fusion Gene

Known as: AML1/ETO FUSION GENE, ETO/AML FUSION GENE, AML/ETO Fusion Gene 
A fusion gene (~4.3 kb) that results from a chromosomal translocation t(8;21)(q22;q22) which fuses the first 5 exons of the RUNX1 gene to exon 2 of… 
National Institutes of Health

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RUNX1/RUNX1T1 Fusion ProteinTranscriptional Repression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
U2AF1 mutation types in primary myelofibrosis: phenotypic and prognostic distinctions
myeloid leukemia. Blood. 2013;121:2213–23. 4. Yin JA, O’Brien MA, Hills RK, Daly SB, Wheatley K, Burnett AK. Minimal residual… 
2010
2010
Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT
MLL/AF4 and AML/MTG8 represent two leukemic fusion genes, which are most frequently found in infant acute lymphoblastic leukemia… 
Highly Cited
2007
Highly Cited
2007
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
The eight twenty-one protein, ETO, is implicated in 12%–15% of acute human leukemias as part of a gene fusion with RUNX1 (also… 
Highly Cited
2003
Highly Cited
2003
AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells.
The translocation t(8;21) yields the leukemic fusion gene AML1/MTG8 and is associated with 10%-15% of all de novo cases of acute… 
Review
2003
Review
2003
The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications.
Highly Cited
2000
Highly Cited
2000
Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF.
The AML1-MTG8 fusion transcription factor generated by t(8;21) translocation is thought to dysregulate genes that are crucial for… 
2000
2000
Quantitation of minimal residual disease in t(8;21)‐positive acute myelogenous leukemia patients using real‐time quantitative RT‐PCR
t(8;21) is one of the common chromosomal translocations in acute myelogenous leukemia (AML). Using a recently developed real‐time… 
Highly Cited
1998
Highly Cited
1998
The AML1-MTG8 Leukemic Fusion Protein Forms a Complex with a Novel Member of the MTG8(ETO/CDR) Family, MTGR1
ABSTRACT The AML1-CBFβ transcription factor complex is essential for the definitive hematopoiesis of all lineages and is the most… 
Highly Cited
1998
Highly Cited
1998
Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein.
A monkey kidney cDNA that encodes a nuclear regulatory factor was identified by expression and affinity binding to a synthetic… 
Highly Cited
1995
Highly Cited
1995
Establishment of a myeloid leukaemic cell line (SKNO‐1) from a patient with t(8;21) who acquired monosomy 17 during disease progression
A novel cell line SKNO‐1 was established from the bone marrow cells of a 22‐year‐old male suffering from acute myeloblastic… 
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