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ROCK2 Inhibitor KD025

Known as: SLx2119, SLx 2119, ROCK-II Inhibitor KD025 
An orally administered inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II), with potential immunomodulating activity. Upon… 
National Institutes of Health

Papers overview

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2019
2019
KD025 for Patients with Chronic Graft-Versus-Host Disease (cGVHD) - Long-Term Follow-up of a Phase 2a Study (KD025-208)
Introduction: cGVHD exhibits both autoimmune and fibrotic features across multiple organ systems. KD025 is an orally available… 
2019
2019
KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells
ABSTRACT Rho-associated kinases (ROCKs) have been reported to antagonize adipocyte differentiation, and inhibition of ROCKs by… 
2018
2018
Changes in Cerebral Arteries and Parenchymal Arterioles With Aging: Role of Rho Kinase 2 and Impact of Genetic Background
Vascular aging fundamentally contributes to large and small vessel disease. Despite the importance of such changes for brain… 
2018
2018
Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.
2018
2018
The selective ROCK2 inhibitor KD025 reduces IL‐17 secretion in human peripheral blood mononuclear cells independent of IL‐1 and IL‐6
Reducing the activities of the pro‐inflammatory cytokine IL‐17 is an effective treatment strategy for several chronic autoimmune… 
2018
2018
Initial Results of KD025-208: A Phase 2a Open-Label Clinical Trial of KD025 for Steroid-Dependent Chronic Graft Versus Host Disease (cGVHD)
2012
2012
Experiencia en Cuba del tratamiento de la litiasis renoureteral con litotricia extracorpórea por ondas de choque en niños
Introduccion: la litiasis urinaria en el nino resulta una enfermedad poco frecuente si se compara con su incidencia en el adulto… 
2009
2009
[Prospective trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi].
PURPOSE To compare the efficacy of ureteroscopy and extracorporeal shock wave lithotripsy (ESWL) in treating distal ureteral… 
2005
2005
Effects of SLx-2119, a novel small molecule inhibitor of Rho-associated kinase ROCK (ROK), on growth of human tumor xenografts in nude mice
668 A Ser/Thr kinase ROCK (Rho-associated coiled-coil forming protein kinase) is a downstream effector of small Ras-like GTPase… 
2005
2005
1686: Higher Treatment Efficacy with the HM3 or Treatment Comfort with the Modulith SLX for Urinary Stones: What Would the Patient Choose?
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