Effects of SLx-2119, a novel small molecule inhibitor of Rho-associated kinase ROCK (ROK), on growth of human tumor xenografts in nude mice

@inproceedings{Shifrin2005EffectsOS,
  title={Effects of SLx-2119, a novel small molecule inhibitor of Rho-associated kinase ROCK (ROK), on growth of human tumor xenografts in nude mice},
  author={Victor I. Shifrin and Robert R. Annand and Deborah A. Flusberg and Sharon McGonigle and Eric T. Wong and Elsa Paradise and Alessandra Bartolozzi and Siya Ram and Hope Foudoulakis and Brian Kirk and Richard Chesworth and Steven Wayne Riesinger and Michael A. Grogan and Katya Tsaioun and Amanda Malchoff and Elena Ter-Ovanesyan and Roger Waechter and David L Duffy and Enoch Kim and Olivier Schueller and Stewart A. Campbell},
  year={2005}
}
668 A Ser/Thr kinase ROCK (Rho-associated coiled-coil forming protein kinase) is a downstream effector of small Ras-like GTPase Rho. The Rho-ROCK signaling pathway controls cell shape, adhesion, contractility, and cell motility and invasion. Thus, testing of ROCK inhibitors in animal models of cancer was previously focused mostly on their anti-metastatic effects. The goal of the present study however, was to determine whether a novel class of ROCK-selective protein kinase inhibitors will… CONTINUE READING

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