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RNA-directed RNA polymerase activity

Known as: RNA replicase activity, RNA-dependent RNA polymerase activity, RNA-dependent RNA replicase activity 
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. [EC:2.7.7.48, GOC:mah]
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse… Expand
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Highly Cited
2007
Highly Cited
2007
In Caenorhabditis elegans, an effective RNA interference (RNAi) response requires the production of secondary short interfering… Expand
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Highly Cited
2007
Highly Cited
2007
Dengue fever, a neglected emerging disease for which no vaccine or antiviral agents exist at present, is caused by dengue virus… Expand
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Highly Cited
2002
Highly Cited
2002
RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans. Unfortunately, RNAi does not inhibit all genes… Expand
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Highly Cited
2002
Highly Cited
2002
RNA interference (RNAi) is the process of sequence-specific, posttranscriptional gene silencing in animals and plants initiated… Expand
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Highly Cited
2001
Highly Cited
2001
We have investigated the role of trigger RNA amplification during RNA interference (RNAi) in Caenorhabditis elegans. Analysis of… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Cell-fate determination requires that cells choose between alternative developmental pathways. For example, germ cells… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Hepatitis C virus (HCV) is the major etiological agent of hepatocellular carcinoma, and HCV RNA-dependent RNA… Expand
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Highly Cited
1997
Highly Cited
1997
The NS5B protein of the hepatitis C virus (HCV) is an RNA-dependent RNA polymerase (RdRp) (S.-E. Behrens, L. Tomei, and R. De… Expand
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Highly Cited
1995
Highly Cited
1995
The sequence of the entire genome of citrus tristeza virus (CTV), Florida isolate T36, was completed. The 19,296-nt CTV genome… Expand
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