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RNA-directed RNA polymerase activity

Known as: RNA replicase activity, RNA-dependent RNA polymerase activity, RNA-dependent RNA replicase activity 
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template. [EC:2.7.7.48, GOC:mah]
National Institutes of Health

Related topics

Related topics

5 relations
RNA-Directed RNA Polymerasenegative regulation of RNA-directed RNA polymerase activitypolymerase Lpositive regulation of RNA-directed RNA polymerase activity

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phage f2 replicase

Papers overview

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Highly Cited
2010
Highly Cited
2010
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
Positive-strand RNA viruses include a large number of human and animal pathogens whose essential RNA-dependent RNA polymerases… 
Highly Cited
2007
Highly Cited
2007
Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class
In Caenorhabditis elegans, an effective RNA interference (RNAi) response requires the production of secondary short interfering… 
Highly Cited
2007
Highly Cited
2007
RNAi for insect-proof plants
RNA interference induced in insects after ingestion of plant-expressed hairpin RNA offers promise for managing devastating crop… 
Highly Cited
2005
Highly Cited
2005
RDR6 Has a Broad-Spectrum but Temperature-Dependent Antiviral Defense Role in Nicotiana benthamiana
ABSTRACT SDE1/SGS2/RDR6, a putative RNA-dependent RNA polymerase (RdRP) from Arabidopsis thaliana, has previously been found to… 
Highly Cited
2001
Highly Cited
2001
RNAi as Random Degradative PCR siRNA Primers Convert mRNA into dsRNAs that Are Degraded to Generate New siRNAs
Highly Cited
2000
Highly Cited
2000
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
Highly Cited
1999
Highly Cited
1999
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
Highly Cited
1999
Highly Cited
1999
Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
ABSTRACT Production of soluble full-length nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) has been shown to be… 
Highly Cited
1998
Highly Cited
1998
RNA-dependent RNA Polymerase Activity of the Soluble Recombinant Hepatitis C Virus NS5B Protein Truncated at the C-terminal Region*
The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase (RdRP), which is the central catalytic enzyme of… 
Highly Cited
1997
Highly Cited
1997
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
The NS5B protein of the hepatitis C virus (HCV) is an RNA-dependent RNA polymerase (RdRp) (S.-E. Behrens, L. Tomei, and R. De… 
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