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Processing of primary microRNAs by the Microprocessor complex
A role for Pasha is indicated in miRNA maturation and miRNA-mediated gene regulation in mature microRNAs and in the post-transcriptional level.
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
The zebrafish reference genome sequence and its relationship to the human genome
A high-quality sequence assembly of the zebrafish genome is generated, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map, providing a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebra fish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.
A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map
Single nucleotide polymorphisms (SNPs) are valuable genetic markers of human disease. They also comprise the highest potential density marker set available for mapping experimentally derived…
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
- R. Ketting, S. Fischer, E. Bernstein, T. Sijen, G. Hannon, R. Plasterk
- BiologyGenes & development
- 15 October 2001
A combination of phenotypic abnormalities and RNA analysis suggests a role for dcr-1 in a regulatory pathway comprised of small temporal RNA (let-7) and its target (e.g., lin-41).
MicroRNA Expression in Zebrafish Embryonic Development
Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
- S. Berghmans, R. Murphey, A. Look
- BiologyProceedings of the National Academy of Sciences…
- 3 January 2005
These mutant zebrafish lines provide a unique platform for modifier screens to identify genetic mutations or small molecules that affect tp53-related pathways, including apoptosis, cell-cycle delay, and tumor suppression.
Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi
Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class
Cloned secondary siRNAs from transgenic C. elegans lines expressing a single 22-nucleotide primary siRNA indicated that non–RISC (RNA-induced silencing complex)–cleaved mRNAs are substrates for secondary siRNA production, infer that RdRPs perform unprimed RNA synthesis.