RNA-Induced Silencing Complex

Known as: RISC Multicomponent Nuclease, Silencing Complex, RNA-Induced, Multicomponent Nuclease, RISC 
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
RNA interference (RNAi) is triggered by double-stranded RNA helices that have been introduced exogenously into cells as small… (More)
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Highly Cited
2005
Highly Cited
2005
MicroRNAs (miRNAs) are generated by a two-step processing pathway to yield RNA molecules of approximately 22 nucleotides that… (More)
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Highly Cited
2005
Highly Cited
2005
RNA interference is implemented through the action of the RNA-induced silencing complex (RISC). Although Argonaute2 has been… (More)
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Highly Cited
2005
Highly Cited
2005
ARGONAUTE (AGO) RNA-binding proteins are involved in RNA silencing. They bind to short interfering RNAs (siRNAs) and microRNAs… (More)
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Highly Cited
2004
Highly Cited
2004
Short-interfering RNAs suppress gene expression through a highly regulated enzyme-mediated process called RNA interference (RNAi… (More)
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Highly Cited
2004
Highly Cited
2004
In the Drosophila and mammalian RNA interference (RNAi) pathways, target RNA destruction is catalyzed by the siRNA-guided, RNA… (More)
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Highly Cited
2004
Highly Cited
2004
The RNase III enzyme Dicer processes RNA into siRNAs and miRNAs, which direct a RNA-induced silencing complex (RISC) to cleave… (More)
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Highly Cited
2004
Highly Cited
2004
In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA… (More)
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Highly Cited
2002
Highly Cited
2002
Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of RNA interference (RNAi). Here, we… (More)
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Highly Cited
2001
Highly Cited
2001
RNA interference (RNAi) is the mechanism through which double-stranded RNAs silence cognate genes. In plants, this can occur at… (More)
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