Protein Argonaute-1

Known as: hAgo1, eIF2C 1, Putative RNA-Binding Protein Q99 
Protein argonaute-1 (857 aa, ~97 kDa) is encoded by the human EIF2C1 gene. This protein is involved in RNA-mediated gene silencing.
National Institutes of Health

Papers overview

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2013
2013
Argonautes are the central protein component in small RNA silencing pathways. Of the four human Argonautes (hAgo1-hAgo4) only… (More)
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Highly Cited
2011
Highly Cited
2011
Small RNAs loaded into Argonaute proteins direct silencing of complementary target mRNAs. It has been proposed that multiple… (More)
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Highly Cited
2010
Highly Cited
2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA… (More)
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Highly Cited
2010
Highly Cited
2010
RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral… (More)
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Highly Cited
2008
Highly Cited
2008
Small RNAs triggering RNA silencing are loaded onto Argonautes and then sequence-specifically guide them to target transcripts… (More)
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Highly Cited
2008
Highly Cited
2008
MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level in the cytoplasm, but recent findings suggest… (More)
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Highly Cited
2005
Highly Cited
2005
AU-rich elements (AREs) in the 3' untranslated region (UTR) of unstable mRNAs dictate their degradation. An RNAi-based screen… (More)
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) are endogenous 21-24-nt RNAs that can down-regulate gene expression by pairing to the messages of protein… (More)
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Highly Cited
2002
Highly Cited
2002
Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of RNA interference (RNAi). Here, we… (More)
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Highly Cited
2000
Highly Cited
2000
Introduction of transgene DNA may lead to specific degradation of RNAs that are homologous to the transgene transcribed sequence… (More)
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