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Protein Argonaute-1

Known as: hAgo1, eIF2C 1, Putative RNA-Binding Protein Q99 
Protein argonaute-1 (857 aa, ~97 kDa) is encoded by the human EIF2C1 gene. This protein is involved in RNA-mediated gene silencing.
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA… Expand
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Highly Cited
2006
Highly Cited
2006
RNA silencing refers to small regulatory RNA-mediated processes that repress endogenous gene expression and defend hosts from… Expand
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Highly Cited
2006
Highly Cited
2006
Drosophila Polycomb group (PcG) proteins silence homeotic genes through binding to Polycomb group response elements (PREs). Fab-7… Expand
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Highly Cited
2005
Highly Cited
2005
AU-rich elements (AREs) in the 3' untranslated region (UTR) of unstable mRNAs dictate their degradation. An RNAi-based screen… Expand
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Highly Cited
2004
Highly Cited
2004
In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA… Expand
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) are endogenous 21-24-nt RNAs that can down-regulate gene expression by pairing to the messages of protein… Expand
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Highly Cited
2004
Highly Cited
2004
Gene regulation by RNA interference requires the functions of the PAZ domain protein Argonaute. In plants, mutations in… Expand
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Highly Cited
2003
Highly Cited
2003
Heritable, but reversible, changes in transposable element activity were first observed in maize by Barbara McClintock in the… Expand
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Highly Cited
2002
Highly Cited
2002
Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of RNA interference (RNAi). Here, we… Expand
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Highly Cited
1999
Highly Cited
1999
Several lines of evidence indicate that the adaxial leaf domain possesses a unique competence to form shoot apical meristems… Expand
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