RNA, Guide

Known as: Guide RNA, gRNA (guide RNA), RNA, Guide [Chemical/Ingredient] 
Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and… (More)

Topic mentions per year

Topic mentions per year

1982-2018
010020019822018

Papers overview

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Highly Cited
2014
Highly Cited
2014
Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with… (More)
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Highly Cited
2014
Highly Cited
2014
RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome… (More)
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Highly Cited
2014
Highly Cited
2014
RNA-guided engineered nucleases (RGENs) derived from the prokaryotic adaptive immune system known as CRISPR (clustered, regularly… (More)
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Highly Cited
2013
Highly Cited
2013
Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats… (More)
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Highly Cited
2013
Highly Cited
2013
The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs… (More)
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Highly Cited
2013
Highly Cited
2013
Targeted nucleases are powerful tools for mediating genome alteration with high precision. The RNA-guided Cas9 nuclease from the… (More)
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Highly Cited
2013
Highly Cited
2013
Precise and straightforward methods to edit the plant genome are much needed for functional genomics and crop improvement… (More)
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Highly Cited
2013
Highly Cited
2013
The RNA-programmable Cas9 endonuclease cleaves double-stranded DNA at sites complementary to a 20-base-pair guide RNA. The Cas9… (More)
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Highly Cited
2005
Highly Cited
2005
RNA interference (RNAi) is a conserved sequence-specific gene regulatory mechanism mediated by the RNA-induced silencing complex… (More)
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Highly Cited
1990
Highly Cited
1990
A class of small RNA molecules possibly involved in RNA editing is present in the mitochondrion of Leishmania tarentolae. These… (More)
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