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Clinical characteristics of 82 death cases with COVID-19
TLDR
Older males with comorbidities are more likely to develop severe disease, even die from SARS-CoV-2 infection, but either virus itself or cytokine release storm mediated damage to other organ including cardiac, renal, hepatic, and hemorrhage should be taken seriously as well. Expand
The role of TLRs in cervical cancer with HPV infection: a review
TLDR
In cervical cancer caused by HR-HPV infection, Toll-like receptors have been found to regulate the local immune microenvironment and its relationship with HPV vaccine is reviewed. Expand
Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis
TLDR
Screening for DEGs and pathways in ovarian cancer using integrated bioinformatics analyses could help to understand the molecular mechanism underlying the development of ovarian cancer, be of clinical significance for the early diagnosis and prevention of Ovarian cancer, and provide effective targets for the treatment of ovariancancer. Expand
How does hypoxia inducible factor-1α participate in enhancing the glycolysis activity in cervical cancer?
TLDR
Strong up-regulation and the role of HIF-1α suggest that Hif-1 α could be an important factor in the onset and progression of cervical cancer and could be a attractive therapeutic molecular target for that type of cancer. Expand
The mechanism of lipid raft mediating chemoresistance of cervical cancer.
TLDR
Lipid raft may up-regulate ROS level and HIF-1alpha expression through activating NADPH oxidase, and thus promote chemotherapy resistance in cervical cancer. Expand
Identification of differentially expressed genes and signaling pathways involved in endometriosis by integrated bioinformatics analysis
TLDR
The results revealed that the DEGs were closely associated with cell migration, adherens junction and hypoxia-inducible factor signaling, and immunohistochemical assay results were found to be consistent with the bioinformatics results. Expand
CTLA4 has a profound impact on the landscape of tumor-infiltrating lymphocytes with a high prognosis value in clear cell renal cell carcinoma (ccRCC)
TLDR
CTLA4 was up-regulated in ccRCC tissues and closely related to the disease progression as well as a poor prognosis, and was markedly correlated with multiple immune checkpoints, which suggested thatccRCC patients with high expressed CTLA4 may benefit more from immune checkpoint blockades (ICBs) combined therapy. Expand
TLR4 May Accelerate Hypoxia Reaction to Promote the Occurrence and Progress of Cervical Lesions by Infected Pathogenic Microorganisms Other than HPV
TLDR
TLR 4 may promote the occurrence and progress of cervical lesions by accelerating the hypoxia reaction and the natural immune reaction mediated by TLR4 may be correlated to other pathogenic microorganisms infecting the cervical tissue, rather than HPV. Expand
Applications of chitin and chitosan nanofibers in bone regenerative engineering.
TLDR
The biomedical applications and biological properties of chitin/chitosan-based nanofibrous scaffolds in bone tissue engineering are outlined and found structurally similar to bone's extracellular matrix and can assist in bone regeneration. Expand
Chitosan/tannic acid bilayers layer-by-layer deposited cellulose nanofibrous mats for antibacterial application.
TLDR
The results of mechanical properties testing and water contact angle measurements of these LBL-structured mats demonstrated that the LBL technology was able to improve their surface characteristics, hydrophilicity and mechanical properties. Expand
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