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RN7SK gene

Known as: RNA, 7SK small nuclear, RNA, 7SK, SMALL NUCLEAR, 7SK 
National Institutes of Health

Related topics

Related topics

2 relations
7SK Small Nuclear RNA, humanRNA, Nuclear

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP
Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA… 
Highly Cited
2010
Highly Cited
2010
The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
Background The positive transcription elongation factor, P-TEFb, is required for the production of mRNAs, however the majority of… 
Highly Cited
2009
Highly Cited
2009
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development
Eukaryotic gene expression is commonly controlled at the level of RNA polymerase II (RNAPII) pausing subsequent to transcription… 
Highly Cited
2009
Highly Cited
2009
A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP
The 7SK snRNP represents a major reservoir of activity where P-TEFb, a general transcription factor key for RNA polymerase II… 
Highly Cited
2008
Highly Cited
2008
The La‐related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
The positive transcription elongation factor b (P‐TEFb) is a heterodimeric complex composed of cyclin‐dependent kinase 9 and its… 
Highly Cited
2007
Highly Cited
2007
The Transcription-Dependent Dissociation of P-TEFb-HEXIM1-7SK RNA Relies upon Formation of hnRNP-7SK RNA Complexes
ABSTRACT The positive transcription elongation factor P-TEFb controls the elongation of transcription by RNA polymerase II. P… 
Highly Cited
2007
Highly Cited
2007
Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P‐TEFb
The 7SK small nuclear RNA (snRNA) regulates RNA polymerase II transcription elongation by controlling the protein kinase activity… 
Highly Cited
2006
Highly Cited
2006
Regulation of Polymerase II Transcription by 7SK snRNA: Two Distinct RNA Elements Direct P-TEFb and HEXIM1 Binding
ABSTRACT The positive transcription elongation factor b (P-TEFb), a complex of Cdk9 and cyclin T1/T2, stimulates transcription by… 
Highly Cited
2005
Highly Cited
2005
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P‐TEFb
Transcription elongation of eukaryotic genes by RNA polymerase II depends on the positive transcription elongation factor b (P… 
Highly Cited
2004
Highly Cited
2004
A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb
ABSTRACT The HEXIM1 protein inhibits the kinase activity of P-TEFb (CDK9/cyclin T) to suppress RNA polymerase II transcriptional… 
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