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RG7787
Known as:
RG 7787
, RG-7787
National Institutes of Health
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Related topics
1 relation
Broader (1)
Immunoconjugates
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes
E. Kolyvas
,
Michael W Rudloff
,
+4 authors
C. Alewine
OncoTarget
2016
Corpus ID: 3587095
Recombinant immunotoxins (RITs) are antibody-based therapeutics that carry a toxin payload. The RG7787 RIT targets the cancer…
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2016
2016
Abstract 1290: Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells
Xiufen Liu
,
Laiman Xiang
,
M. Prunotto
,
G. Niederfellner
,
I. Pastan
2016
Corpus ID: 78361030
Immunotoxins are recombinant fusion proteins that contain an antibody fragment directed against a tumor selective surface antigen…
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2016
2016
Abstract 3103: The reduced immunogenicity anti-mesothelin immunotoxin RG7787 in combination with nab-paclitaxel has significant anti-tumor efficacy against primary mesothelioma cell lines and patient…
Jingli Zhang
,
Q. Jiang
,
+5 authors
R. Hassan
2016
Corpus ID: 56696519
Mesothelin is a tumor differentiation antigen that is highly expressed in many cancers including malignant mesothelioma. RG7787…
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2016
2016
Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1.
Fatima Ali-Rahmani
,
D. FitzGerald
,
+5 authors
I. Pastan
Cancer Research
2016
Corpus ID: 19040118
Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression…
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2015
2015
Abstract 2566: Combination of taxanes with mesothelin-targeted immunotoxin RG7787 induces synergistic killing of pancreatic cancer
C. Alewine
,
E. Kolyvas
,
K. Boslett
,
I. Pastan
2015
Corpus ID: 75962375
Pancreatic cancer has a poor prognosis with a 5 year median overall survival of just 6%. Most pancreatic adenocarcinomas express…
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2015
2015
Abstract 5321: Preclinical validation for treatment with RG7787 in ovarian cancer
Gwendlyn Kollmorgen
,
K. Palme
,
+10 authors
G. Niederfellner
2015
Corpus ID: 57718451
RG7787 is composed of a Fab fragment from an anti-MSLN antibody fused to a de-immunized and truncated pseudomonas endotoxin A…
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2014
2014
Abstract 4505: Anti-tumor activity in pancreatic cancer of a low immunogenic and clinically optimized anti-mesothelin immunotoxin RG7787
I. Pastan
,
K. Hollevoet
,
Emily Mason-Osann
,
C. Alewine
,
Xiujun Liu
2014
Corpus ID: 53891620
Background Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and new therapies are needed. SS1P is a recombinant…
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