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RG 13577

Known as: RG-13577 
 
National Institutes of Health

Papers overview

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2006
2006
Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent
Purpose: To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of… Expand
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2003
2003
A synthetic heparin-mimicking polyanionic compound inhibits central nervous system inflammation
The immunomodulating capacity of heparin led us to test the effect of the synthetic heparin-mimicking and low anticoagulant… Expand
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2002
2002
Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta.
Hypertrophy of vascular smooth muscle cells occurs during hypertension-induced remodelling of arteries and during development of… Expand
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2002
2002
Inhibition of anastomotic intimal hyperplasia by a synthetic nonsulphated heparin-mimicking compound.
Despite extensive research in the design of endovascular catheters and advanced surgical techniques, stenosis recurs in a large… Expand
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2001
2001
A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation.
A synthetic heparin-mimicking polyaromatic anionic compound RG-13577 (polymer of 4-hydroxyphenoxy acetic acid and formaldehyde… Expand
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2001
2001
Effects of the heparin-mimicking compound RG-13577 on lipoprotein lipase and on lipase mediated binding of LDL to cells.
Lipoprotein lipase (LPL) has high affinity for heparin and heparin-like compounds. In vivo the enzyme is attached to heparan… Expand
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1997
1997
Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound.
Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and… Expand
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1997
1997
Endogenous basic fibroblast growth factor displaced by heparin from the lumenal surface of human blood vessels is preferentially sequestered by injured regions of the vessel wall.
BACKGROUND Proliferation of smooth muscle cells (SMCs) of the arterial wall in response to local injury is an important factor in… Expand
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1997
1997
Antiproliferative activity to glomerular mesangial cells and receptor binding of a heparin-mimicking polyaromatic anionic compound.
Proliferation of mesangial cells (MC) is a key feature in the pathogenesis of numerous renal diseases involving the glomerulus… Expand
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1994
1994
Antiproliferative activity to vascular smooth muscle cells and receptor binding of heparin-mimicking polyaromatic anionic compounds.
Proliferation of bovine aortic smooth muscle cells (SMCs) induced by thrombin, basic fibroblast growth factor, or serum is… Expand
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