• Publications
  • Influence
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
TLDR
It is demonstrated here that the N-terminal coiled-coil domain of Angptl-4 binds transiently to LPL and that the interaction results in conversion of the enzyme from catalytically active dimers to inactive, but still folded, monomers with decreased affinity for heparin. Expand
GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.
TLDR
The function of GPIHBP1 in triglyceride metabolism is defined and a mechanism for the transport of LPL into capillaries is provided, which is located at the basolateral surface of capillary endothelial Cells and actively transports LPL across endothelial cells. Expand
Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets*
TLDR
It is shown that Apolipoproteins C-I and C-III inhibit lipolysis by displacing LPL from lipid emulsion particles, and a role is proposed in the irreversible inactivation of LPL by factors such as angptl4. Expand
Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance.
TLDR
Enlarged adipocytes and reduced serum adiponectin, together with a large waistline, rather than androgen excess, may be central factors in the pathogenesis/maintenance of insulin resistance in PCOS. Expand
pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes Published, JLR Papers in Press, November 16, 2002. DOI 10.1194/jlr.M200182-JLR200
TLDR
It is demonstrated that purified pH6-Ag selectively binds to apolipoprotein B (apoB)-containing lipoproteins in human plasma, mainly LDL, indicating that the lipid moiety of the lipoprotein was responsible for the interaction. Expand
Lipoprotein lipase mass and activity in plasma and their increase after heparin are separate parameters with different relations to plasma lipoproteins.
TLDR
There was a relatively large amount of LPL protein compared with LPL activity in preheparin plasma, indicating that the majority of circulating LPL is catalytically inactive, and heparin releases mainly active LPL. Expand
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
TLDR
It is suggested that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis. Expand
Retention of Low-Density Lipoprotein in Atherosclerotic Lesions of the Mouse: Evidence for a Role of Lipoprotein Lipase
TLDR
Retention of LDL in the artery wall is initiated by direct LDL–proteoglycan binding but shifts to indirect binding with bridging molecules such as LPL, and transgenic mice expressing catalytically active or inactive LPL developed the same extent of atherosclerosis. Expand
The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties.
TLDR
It is shown that one RAP molecule can bind to different clusters simultaneously, supporting a model in which RAP binding to LRP induces a conformational change in the receptor that is incompatible with ligand binding. Expand
Interaction of lipoprotein lipase with heparin fragments and with heparan sulfate: stoichiometry, stabilization, and kinetics.
TLDR
An essential role of electrostatic steering in the association of lipoprotein lipase with heparan sulfate and with size-fractionated fragments of heparin is proposed and a model for binding of LPL to heparn sulfate-covered surfaces is proposed. Expand
...
1
2
3
4
5
...