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RASA1 wt Allele

Known as: RAS p21 Protein Activator (GTPase Activating Protein) 1 wt Allele, CMAVM, p120RASGAP 
Human RASA1 wild-type allele is located in the vicinity of 5q13.3 and is approximately 124 kb in length. This allele, which encodes Ras GTPase… 
National Institutes of Health

Related topics

Related topics

18 relations
Axon GuidanceB Cell Receptor Signaling PathwayCAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION (disorder)EGF Signaling Pathway

Narrower (2)

GTPase-Activating ProteinsRas GTPase-Activating Protein 1

Broader (1)

RASA1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos
ERK1/2 MAP kinase exhibits a highly dynamic activation pattern in developing embryos, which largely depends on fibroblast growth… 
Highly Cited
2007
Highly Cited
2007
A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.
In primary human T cells, anergy induction results in enhanced p59Fyn activity. Because Fyn is the kinase primarily responsible… 
2005
2005
Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157.
RasGAP bears two caspase-3 cleavage sites that are used sequentially as caspase activity increases in cells. When caspase-3 is… 
2002
2002
Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.
The low-affinity receptor for IgG, Fc gamma RIIB, is expressed widely in the immune system and functions to attenuate Ag-induced… 
Highly Cited
2001
Highly Cited
2001
Antiapoptotic Signaling Generated by Caspase-Induced Cleavage of RasGAP
ABSTRACT Activation of caspases 3 and 9 is thought to commit a cell irreversibly to apoptosis. There are, however, several… 
Highly Cited
1998
Highly Cited
1998
Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.
1995
1995
CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein.
CaLB was originally observed as a conserved sequence motif in various calcium-responsive signalling proteins and also in p120 Ras… 
Highly Cited
1994
Highly Cited
1994
Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth
The p210bcr/abl tyrosine kinase appears to be responsible for initiating and maintaining the leukemic phenotype in chronic… 
1994
1994
The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP.
There are two closely related, but distinct platelet-derived growth factor receptor (PDGFR) subunits: alpha and beta. Recent… 
1993
1993
Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction
The GTPase activity of p21ras is stimulated by GTPase-activating proteins (GAPs) such as p120GAP and the product of the… 
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