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RAPGEF4 gene

Known as: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR, EPAC2, cAMP-GEFII 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions through incompletely understood mechanisms… Expand
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Review
2010
Review
2010
  • M. Gloerich, J. Bos
  • Annual review of pharmacology and toxicology
  • 2010
  • Corpus ID: 37351100
cAMP is a second messenger that is essential for relaying hormonal responses in many biological processes. The discovery of the… Expand
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Highly Cited
2009
Highly Cited
2009
Expanding Sulfonylurea Mechanisms Sulfonylureas are important drugs used for treatment of diabetes that act through adenosine… Expand
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Highly Cited
2007
Highly Cited
2007
cAMP is well known to regulate exocytosis in various secretory cells, but the precise mechanism of its action remains unknown… Expand
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Highly Cited
2007
Highly Cited
2007
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including… Expand
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Review
2006
Review
2006
  • J. Bos
  • Trends in biochemical sciences
  • 2006
  • Corpus ID: 37340794
Epac1 and Epac2 are cAMP-dependent guanine-nucleotide-exchange factors for the small GTPases Rap1 and Rap2, and are known to be… Expand
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Highly Cited
2006
Highly Cited
2006
Epac proteins (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors (GEFs) for the small GTP… Expand
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Review
2004
Review
2004
  • G. Holz
  • Diabetes
  • 2004
  • Corpus ID: 24782689
Recently published studies of islet cell function reveal unexpected features of glucagon-like peptide-1 (GLP-1) receptor-mediated… Expand
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Highly Cited
2003
Highly Cited
2003
  • J. Bos
  • Nature Reviews Molecular Cell Biology
  • 2003
  • Corpus ID: 10648813
Five years ago, Epac — a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2 — was found to be a new… Expand
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Highly Cited
2000
Highly Cited
2000
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1… Expand
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