FAQ

RAPGEF4 gene

Known as: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR, EPAC2, cAMP-GEFII 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
02420012017

Related topics

Related topics

1 relation
RAPGEF3 gene

Related mentions per year

Related mentions per year

1989-2018
19801990200020102020
RAPGEF4 gene
RAPGEF3 gene

Papers overview

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2015
2015
Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.
Exchange proteins directly activated by cAMP (Epac1 and Epac2) have been recently recognized as key players in β-adrenergic… (More)
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2014
2014
The role of exchange protein directly activated by cyclic AMP 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells.
Decidualization of human endometrial stromal cells (ESCs) accompanied by the production of prolactin (PRL) and IGF-binding… (More)
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2014
2014
Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus.
The optimal decidualization of endometrial stromal cells (ESCs) following embryo implantation is one of the critical steps to… (More)
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2013
2013
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome.
Previously, exchange protein directly activated by cAMP 2 (Epac2) and PKA were known to play a role in glucose-stimulated insulin… (More)
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2013
2013
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and… (More)
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2011
2011
Direct activation of Epac by sulfonylurea is isoform selective.
Commonly used as a treatment for Type II diabetes, sulfonylureas (SUs) stimulate insulin secretion from pancreatic β cells by… (More)
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2011
2011
Guanine-nucleotide exchange factors (RAPGEF3/RAPGEF4) induce sperm membrane depolarization and acrosomal exocytosis in capacitated stallion sperm.
Capacitation encompasses the molecular changes sperm undergo to fertilize an oocyte, some of which are postulated to occur via a… (More)
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2010
2010
Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2.
CRF-induced ERK phosphorylation has been shown to be an important mechanism underlying expression of pro-opiomelanocortin, a key… (More)
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Highly Cited
2009
Highly Cited
2009
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
Dynamic remodeling of spiny synapses is crucial for cortical circuit development, refinement and plasticity, whereas abnormal… (More)
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2001
2001
Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform.
The liver-specific protein cAMP-GEFII (also known as Epac2) belongs to a family of cyclic adenosine monophosphate (cAMP) binding… (More)
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