Skip to search formSkip to main contentSkip to account menu

RAPGEF3 gene

Known as: EXCHANGE PROTEIN ACTIVATED BY cAMP, EPAC1, Rap guanine nucleotide exchange factor 3 
National Institutes of Health

Related topics

Related topics

1 relation
RAPGEF4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8‐CPT‐2Me‐cAMP, in prostate cancer cells: Assembly of a multiprotein signaling complex
Ligation of cell surface‐associated GRP78 by activated α2‐macroglobulin triggers pro‐proliferative cellular responses. In part… 
2012
2012
Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A.
Glucokinase (GK), which phosphorylates D-glucose, is a major glucose sensor in β-cells for glucose-stimulated insulin secretion… 
Highly Cited
2011
Highly Cited
2011
A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells*
Enzymes of the phosphodiesterase 3 (PDE3) and PDE4 families each regulate the activities of both protein kinases A (PKAs) and… 
Highly Cited
2010
Highly Cited
2010
Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins
ABSTRACT Epac1 is a guanine nucleotide exchange factor for the small G protein Rap and is involved in membrane-localized… 
2010
2010
Radixin Assembles cAMP Effectors Epac and PKA into a Functional cAMP Compartment
cAMP is an ubiquitous second messenger. Localized areas with high cAMP concentration, i.e. cAMP microdomains, provide an elegant… 
2010
2010
Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells.
BACKGROUND The mononuclear villous cytotrophoblast (CTB) differentiates and fuses to the multinucleated syncytiotrophoblast (STB… 
Highly Cited
2009
Highly Cited
2009
Activation of Protein Kinase Cα by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein β-dependent Induction of the SOCS-3 Gene by Cyclic AMP in COS1 Cells*
We recently found that induction of the anti-inflammatory SOCS-3 gene by cyclic AMP occurs through novel cyclic AMP-dependent… 
Highly Cited
2008
Highly Cited
2008
PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.
Highly Cited
2008
Highly Cited
2008
Activation of Epac stimulates integrin-dependent homing of progenitor cells.
Cell therapy is a novel promising option for treatment of ischemic diseases. Administered endothelial progenitor cells (EPCs) are… 
Highly Cited
2001
Highly Cited
2001
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
Epac1 is a Rap-specific guanine-nucleotide exchange factor (GEF) which is activated by the binding of cAMP to a cyclic nucleotide… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)