FAQ

RAPGEF3 gene

Known as: EXCHANGE PROTEIN ACTIVATED BY cAMP, EPAC1, Rap guanine nucleotide exchange factor 3 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
0102019892018

Related topics

Related topics

1 relation
RAPGEF4 gene

Related mentions per year

Related mentions per year

1989-2018
19801990200020102020
RAPGEF3 gene
RAPGEF4 gene

Papers overview

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2014
2014
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways.
There is a considerable resurgence of interest in the role of aerobic glycolysis in cancer; however, increased glycolysis is… (More)
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2013
2013
Opposing Roles of pka and epac in the cAMP-Dependent Regulation of Schwann Cell Proliferation and Differentiation
In Schwann cells (SCs), cyclic adenosine monophosphate (cAMP) not only induces differentiation into a myelinating SC-related… (More)
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2012
2012
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
The major physiological effects of cAMP in mammalian cells are transduced by two ubiquitously expressed intracellular cAMP… (More)
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2010
2010
Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.
Vascular endothelial cell (VEC) permeability is largely dependent on the integrity of vascular endothelial cadherin (VE-cadherin… (More)
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2008
2008
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
We identify a compartmentalized signaling system that identifies a functional role for the GTP exchange factor, exchange protein… (More)
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2008
2008
Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.
Exchange proteins directly activated by cAMP (EPACs) are guanine nucleotide-exchange factors for the small GTPases Rap1 and Rap2… (More)
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2008
2008
Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.
Vascular remodeling after mechanoinjury largely depends on the migration of smooth muscle cells, an initial key step to wound… (More)
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2007
2007
A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway
A chemical biology approach identifies a beta 2 adrenergic receptor (β2AR) agonist ARA-211 (Pirbuterol), which causes apoptosis… (More)
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2006
2006
Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting.
We have previously demonstrated that EPAC1 interacts with light chain (LC) 2 of microtubule-associated protein (MAP) 1A. In the… (More)
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2006
2006
Presynaptic mechanism underlying cAMP-induced synaptic potentiation in medial prefrontal cortex pyramidal neurons.
cAMP, a classic second messenger, has been proposed recently to participate in regulating prefrontal cortical cognitive functions… (More)
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