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RAPGEF3 gene

Known as: EXCHANGE PROTEIN ACTIVATED BY cAMP, EPAC1, Rap guanine nucleotide exchange factor 3 
 
National Institutes of Health

Related topics

Related topics

1 relation
RAPGEF4 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion
Exchange protein directly activated by cAMP (EPAC) and cAMP-dependent protein kinase (PKA) are two intracellular receptors that… Expand
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Highly Cited
2006
Highly Cited
2006
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.
Epac-1 and -2 (exchange proteins directly activated by cyclic AMP) are guanine-nucleotide exchange factors for the GTPases Rap1… Expand
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Highly Cited
2005
Highly Cited
2005
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Cyclic adenosine 3′, 5′-monophosphate (cAMP) is a ubiquitous mediator of intracellular signalling events. It acts principally… Expand
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Highly Cited
2005
Highly Cited
2005
cAMP-binding protein Epac induces cardiomyocyte hypertrophy.
cAMP is one of the most important second messenger in the heart. The discovery of Epac as a guanine exchange factor (GEF), which… Expand
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Highly Cited
2004
Highly Cited
2004
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
Epac1 is a guanine nucleotide exchange factor for Rap1 that is activated by direct binding of cAMP. In vitro studies suggest that… Expand
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Review
2004
Review
2004
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell.
Recently published studies of islet cell function reveal unexpected features of glucagon-like peptide-1 (GLP-1) receptor-mediated… Expand
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Highly Cited
2004
Highly Cited
2004
Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion*
The small GTPase Rap is best characterized as a critical regulator of integrin-mediated cell adhesion, although its mechanism of… Expand
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Highly Cited
2003
Highly Cited
2003
cAMP Analog Mapping of Epac1 and cAMP Kinase
Little is known about the relative role of cAMP-dependent protein kinase (cAPK) and guanine exchange factor directly activated by… Expand
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Highly Cited
2003
Highly Cited
2003
Structure and regulation of the cAMP-binding domains of Epac2
Cyclic adenosine monophosphate (cAMP) is a universal second messenger that, in eukaryotes, was believed to act only on cAMP… Expand
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Highly Cited
2003
Highly Cited
2003
Crosstalk between Rap1 and Rac regulates secretion of sAPPα
Cyclic AMP (cAMP) is produced by activation of Gs protein-coupled receptors and regulates many physiological processes through… Expand
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