Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2

@article{Kolen2010CorticotropinRF,
  title={Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2},
  author={Kristof Van Kolen and Karin Verstraeten and Ines Royaux and Ronald de Hoogt and Pieter Johan Peeters},
  journal={Neuropharmacology},
  year={2010},
  volume={58},
  pages={135-144}
}
CRF-induced ERK phosphorylation has been shown to be an important mechanism underlying expression of pro-opiomelanocortin, a key precursor molecule in the hypothalamic pituitary adrenal axis. In AtT20 cells, CRF signalling has been investigated but the mechanism behind CRF-induced ERK activity is not fully understood. This paper elucidates the signalling cascade involved in this phenomenon. Involvement of CRF(1) receptor on ERK phosphorylation was shown by using CRF and urocortin 1. The lack of… CONTINUE READING
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