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4-Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO), has been shown to induce apoptosis… Expand Abstract Oxidative stress and lipid peroxidation (LPO) accompanying infections and chronic inflammation may induce several human… Expand Mitochondria exist as dynamic interconnected networks that are maintained through a balance of fusion and fission. Equal… Expand Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger multiple signaling cascades that variably affect… Expand Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear… Expand In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in… Expand To explore the role of lipid peroxidation (LPO) products in the initial phase of stress mediated signaling, we studied the effect… Expand Active transport of conjugated and unconjugated electrophiles out of cells is essential for cellular homeostasis. We have… Expand RLIP76 is a modular protein that was identified as a putative effector of Ral, a GTPase activated during Ras signaling. To… Expand RalA and RalB are GTPases of unknown function and are activated by proteins, RalGDS, that interact with the active form of… Expand