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RAB8A gene

Known as: ONCOGENE MEL, RAB8A, MEL 
This gene plays a role in signal transduction and protein trafficking.
National Institutes of Health

Related topics

Related topics

7 relations
Homo sapiensRAB8B geneRab8 proteinSignal Transduction

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RAB8A wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A
Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are a common cause of hereditary Parkinson's disease… 
Highly Cited
2012
Highly Cited
2012
MICAL‐L1 is a Tubular Endosomal Membrane Hub that Connects Rab35 and Arf6 With Rab8a
Endocytosis is a conserved process across species in which cell surface receptors and lipids are internalized from the plasma… 
2012
2012
Rab8 Modulates Metabotropic Glutamate Receptor Subtype 1 Intracellular Trafficking and Signaling in a Protein Kinase C-Dependent Manner
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors (GPCRs) that are activated by glutamate, the primary… 
Highly Cited
2010
Highly Cited
2010
Rab8 Interacts with Distinct Motifs in α2B- and β2-Adrenergic Receptors and Differentially Modulates Their Transport*
The molecular mechanism underlying the post-Golgi transport of G protein-coupled receptors (GPCRs) remains poorly understood… 
Highly Cited
2002
Highly Cited
2002
The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression
The 3′ Ig heavy chain locus (Igh) regulatory region is the most downstream known element of the murine Igh gene cluster. We… 
1999
1999
Correct function of the locus control region may require passage through a nonerythroid cellular environment.
The function of the beta-globin locus control region (LCR) has been studied both in cell lines and in transgenic mice. We have… 
Highly Cited
1996
Highly Cited
1996
In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.
Rab8 is a small GTP-binding protein that plays a role in vesicular transport from the trans-Golgi network to the basolateral… 
1990
1990
Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19.
Review
1980
Review
1980
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
Sera of 106 normal adult men were tested for antibodies reacting with cell surface antigens of three established lines of… 
Highly Cited
1979
Highly Cited
1979
Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids
The human α- and β-globin genes have been activated in MEL × human fibroblast cell hybrids. However, even though the human γ- and… 
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