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R207910

Known as: R 207910, TMC 207, TMC-207 
 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Novel oral regimens composed of new drugs with potent activity against Mycobacterium tuberculosis and no cross-resistance with… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The diarylquinoline TMC207 offers a new mechanism of antituberculosis action by inhibiting mycobacterial ATP synthase… Expand
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Highly Cited
2009
Highly Cited
2009
Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia, and other constitutional symptoms… Expand
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Highly Cited
2008
Highly Cited
2008
The persistence of Mycobacterium tuberculosis despite prolonged chemotherapy represents a major obstacle for the control of… Expand
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Highly Cited
2007
Highly Cited
2007
The lengthy chemotherapy of tuberculosis reflects the ability of a small subpopulation of Mycobacterium tuberculosis bacteria to… Expand
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Highly Cited
2007
Highly Cited
2007
In previous studies, the diarylquinoline R207910 (also known as TMC207) was demonstrated to have high bactericidal activity when… Expand
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Highly Cited
2007
Highly Cited
2007
Diarylquinolines (DARQs) are a new class of potent inhibitors of the ATPase of Mycobacterium tuberculosis. We have created a… Expand
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Highly Cited
2006
Highly Cited
2006
Seven antimicrobials were tested in vitro against 29 clinical isolates of Mycobacterium ulcerans. R207910 demonstrated the lowest… Expand
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Highly Cited
2006
Highly Cited
2006
The atpE gene encoding the subunit c of the ATP synthase of Mycobacterium tuberculosis, the target of the new diarylquinoline… Expand
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Highly Cited
2005
Highly Cited
2005
The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis… Expand
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