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bedaquiline

Known as: Bedaquilina, 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol, 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol 
A diarylquinoline antibiotic that works by inhibiting mycobacterial ATP synthase. TMC207 enhances the antibacterial activity of second-line drug… 
National Institutes of Health

Related topics

Related topics

8 relations
Antimycobacterial agentMycobacterium Infectionsbedaquiline 100 MG Oral Tablet [Sirturo]

Broader (2)

Antitubercular AgentsDiarylquinolines

Narrower (3)

Bedaquiline fumarateR207910Sirturo

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Bedaquiline, pretomanid and linezolid for treatment of extensively drug resistant, intolerant or non-responsive multidrug resistant pulmonary tuberculosis
Background Patients with extensively drug resistant tuberculosis (TB) have limited treatment options with historically poor… 
Review
2018
Review
2018
Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis
Highly Cited
2017
Highly Cited
2017
Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study
Large studies on bedaquiline used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) are… 
Review
2016
Review
2016
New agents for the treatment of drug-resistant Mycobacterium tuberculosis.
Highly Cited
2016
Highly Cited
2016
Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis
ABSTRACT The novel ATP synthase inhibitor bedaquiline recently received accelerated approval for treatment of multidrug-resistant… 
Highly Cited
2016
Highly Cited
2016
Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline
Objectives: Resistance-associated variants (RAVs) in Rv0678, a regulator of the MmpS5-MmpL5 efflux pump, have been shown to lead… 
Highly Cited
2015
Highly Cited
2015
Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen… 
Highly Cited
2015
Highly Cited
2015
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis.
Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to… 
Highly Cited
2015
Highly Cited
2015
Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline
Structure and inhibition mechanism of the anti-TB drug bedaquiline bound to the ATP synthase rotor from Mycobacteria. Multidrug… 
Review
2014
Review
2014
Bedaquiline: a review of human pharmacokinetics and drug-drug interactions.
Bedaquiline has recently been approved for the treatment of pulmonary multidrug-resistant tuberculosis (TB) as part of… 
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