bedaquiline

Known as: Bedaquilina, 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol, 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol 
A diarylquinoline antibiotic that works by inhibiting mycobacterial ATP synthase. TMC207 enhances the antibacterial activity of second-line drug… (More)

Topic mentions per year

Topic mentions per year

2004-2018
02040608020042018

Papers overview

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2016
2016
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen… (More)
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2015
2015
Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to… (More)
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2015
2015
OBJECTIVES It is not fully understood why inhibiting ATP synthesis in Mycobacterium species leads to death in non-replicating… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with… (More)
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2014
2014
Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multi-drug resistant tuberculosis… (More)
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2014
2014
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor… (More)
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2014
2014
The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant tuberculosis. To understand… (More)
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2014
2014
Bedaquiline is a recently approved drug for the treatment of multidrug-resistant tuberculosis. Adverse cardiac and hepatic drug… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND New drugs, but also shorter, better-tolerated regimens are needed to tackle the high global burden of tuberculosis… (More)
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Highly Cited
2012
Highly Cited
2012
The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary… (More)
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