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Quizartinib

Known as: (2E)-N-(4-(3-Chloro-4-Fluoroanilino)-7-(((3S)-Oxolan-3-Yl)Oxy)Quinoxazolin-6-yl)-4-(Dimethylamino)but-2-Enamide, AC220 compound, N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo [2,1-b] [1,3] benzothiazol 2-yl]phenyl}urea 
An orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases… 
National Institutes of Health

Related topics

Related topics

6 relations
AC220NCIt Antineoplastic Agent TerminologyQuizartinib DihydrochlorideReceptor Tyrosine Kinase Inhibition

Broader (2)

BenzothiazolesPhenylurea Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Synthesis and Study of the Biological Activity of Some Cyclohexenone Derivatives
In this work, pyrazoline (A1) was prepared from reaction ethyl acetoacetate and 2-hydrazeno benzothiazol that was prepared from… 
2017
2017
FGF 2 from marrow microenvironment promotes resistance to FLT 3 inhibitors in acute myeloid leukemia
Potent FLT3 inhibitors such as quizartinib (AC220) have shown promise in treating acute myeloid leukemia (AML) containing FLT3… 
2016
2016
TITLE: FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia Short title: FGF2 PROMOTES RESISTANCE IN FLT3 AML
Elie Traer, Jacqueline Martinez, Nathalie Javidi-Sharifi, Anupriya Agarwal, Jennifer Dunlap, Isabel English, Tibor Kovacsovics… 
2015
2015
Crystal Structure of the FLT 3 Kinase Domain Bound to the Inhibitor Quizartinib ( AC 220 )
More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like… 
2015
2015
Phospholipid prunes actin branches
![Figure][1] This time-lapse series shows that actin filaments “de-branch” in the presence of cortactin and PI(3,5)P2. A… 
Review
2013
Review
2013
Efficacy and resistance of molecularly targeted therapy for myeloid malignancies FLT 3 inhibitors for acute myeloid leukemia : a review of their efficacy and mechanisms of resistance
Since the Food and Drug Administration approval of imatinib for treatment of chronic myeloid leukemia in 2001, tyrosine kinase… 
2012
2012
Therapeutic Discovery Breakdown of the FLT 3-ITD / STAT 5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT 3-Speci fi c Inhibitors
Activatingmutations of the class III receptor tyrosinekinase FLT3are themost frequentmolecular aberration in acutemyeloid… 
2012
2012
Synthesis and Spectrophotometric Study of 4-( 6-Bromo-2-benzothiazolylazo ) phloroglucinol as an Analytical Reagent for Determination of Bismuth .
A new chromogenic reagent, 4-(6-Bromo-2-benzothiazolylazo)phloroglucinol (6-BrBTAPG), was synthesized by diazo coupling of(2… 
1987
1987
[Perhydropyrrolo [2,1-b] thiazolones: synthesis and study of their chemical and pharmacologic properties].
1979
1979
[Erythrocyte bilirubin determination (author's transl)].
The erythrocyte bilirubin value is of great interest in neonate pathology. Its sudden rising reflects the overbinding capacity to… 
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